Chronic Clinical Trial
Official title:
Chronic Hypoxemia and Systemic Vascular Function
Diseases associated with chronic hypoxemia like chronic obstructive pulmonary disease (COPD)
or emphysema, represent major medical and socio-economical problems and one of the leading
cause of morbidity and mortality in the western countries. Recently, is has been shown that
cardiovascular (CV) diseases contribute highly to the morbidity and mortality of these
patients. Furthermore, increasing evidence suggest that systemic vascular dysfunction play a
central role in the mediation of the increased CV risk in patients with COPD. However the
underlying mechanisms of vascular dysfunction in these patients are incompletely understood.
Chronic mountain sickness (CMS) is characterized by chronic hypoxemia related at least in
part to hypoventilation; it affects relatively young adults, and may therefore allow to study
the effects of chronic hypoxemia. The investigators therefore will assess systemic vascular
function and test the hypothesis that increased oxidative stress is responsible for this
dysfunction. Since polyglobulia is a hallmark of chronic hypoxemia and has been suggested to
affect vascular function, the investigators will test the effects of hemodilution on vascular
function. Then, the investigators will test the effects of acute oxygen application and 1
month antioxidative dietary supplement on vascular function.
Preliminary data suggest that offspring of CMS patients may display pulmonary and systemic
vascular dysfunction. Antioxidant administration is know to improve vascular function. We
will test the acute effect of Vitamin C in this setting.
Finally, since there is considerable inter-individual variability of pulmonary artery
pressure among CMS patients and the presence of a patent foramen ovale (PFO)is increased in
clinical conditions associated with pulmonary hypertension and hypoxemia, we will assess the
prevalence of PFO in healthy high altitude dwellers and in CMS patients and its effects on
pulmonary artery pressure at rest and during mild exercise.
n/a
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