Natural History of Chronic Urticaria

Chronic Urticaria Clinical Trial

— NHCU  

Official title:

The Natural History of Chronic Urticaria in Childhood: A Prospective Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01284426
• Other study ID #: 374/2551(EC3)
• Status: Completed
• Phase: N/A
• First received: January 20, 2011
• Last updated: December 30, 2015
• Start date: March 2003
• Est. completion date: March 2009

Study information

• Verified date: December 2015
• Source: Mahidol University
• Contact: n/a
• Is FDA regulated: No
• Health authority: Thailand: Ethical Committee
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to examine the natural history of chronic urticaria in children and to identify the predictors for chronic urticaria remission.

Description:

A Prospective cohort study of 92 children who were diagnosed with chronic urticaria to investigate the natural course of chronic urticaria and to identify predictors of disease remission.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 94
• Est. completion date: March 2009
• Est. primary completion date: March 2009
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 4 Years to 15 Years

Eligibility

Inclusion Criteria:

• Children 4-15 years of age with the diagnosis of chronic urticaria who were attending the pediatric allergy clinic, Siriraj Hospital Mahidol University, Thailand, from March 2003 to March 2009.

Exclusion Criteria:

• Children who had isolated physical urticaria, inability to be followed up, pregnancy, underlying diseases such as cardiovascular, hepatobiliary, and renal diseases.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Chronic Urticaria
• Urticaria

Locations

Country	Name	City	State
Thailand	Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University	Bangkok

Sponsors (1)

Lead Sponsor	Collaborator
Mahidol University

Country where clinical trial is conducted

Thailand, 

References & Publications (1)

Chansakulporn S, Pongpreuksa S, Sangacharoenkit P, Pacharn P, Visitsunthorn N, Vichyanond P, Jirapongsananuruk O. The natural history of chronic urticaria in childhood: a prospective study. J Am Acad Dermatol. 2014 Oct;71(4):663-8. doi: 10.1016/j.jaad.201 — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Duration of Urticaria Until Remission Since Chronic Urticaria Was Diagnosed.	Remission rates at 1, 3 and 5 years after the onset of symptoms of chronic urticaria.; Description in details: Actually, this study have been started in March 2003 and finally done in March 2009, which would be totally 6 years. We eventually decided to report the rate of CU remissions only at 1, 3 and 5 years after the onset of symptoms because this would be the common interval time of CU symptoms that patients needed to know how long they should have those CU symptoms or how many of them would go away their symptoms within 1, 3 or 5 years. Another reason is that the remission rate of CU between 5 and 6 years was not significantly different, so it might not need to be reported.	6 years	Yes

External Links

•   The natural history of chronic urticaria in childhood: a prospective study.