Clinical Trials Logo

Clinical Trial Summary

This is prospective cohort study in subjects with a planned percutaneous coronary intervention (PCI) of their chronic total occlusion (CTO). The study will enroll subjects who have been scheduled for a clinically-indicated cardiac catheterization, and will evaluate coronary microvascular function in all subjects meeting inclusion criteria with a coronary flow wire. Evaluation of coronary microvascular function may be performed using indirect methods, however the rationale behind the present study is to directly measure microvascular function using direct coronary flow measurements, since the subjects in the study are to undergo a clinically-indicated cardiac catheterization. The overall purpose of the study is to define the presence and severity of coronary microvascular dysfunction subjects with CTO. The study is designed to enroll 50 subjects with CTO in the span of 3 years. There will be a 6-month assessment of the outcomes of death and cardiovascular death. As the study includes FDA approved tests, there will be no safety endpoint per se, however there will be a mechanism for monitoring adverse events as will be described in detail.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04226326
Study type Interventional
Source University of Chicago
Contact
Status Completed
Phase N/A
Start date January 15, 2020
Completion date July 17, 2023

See also
  Status Clinical Trial Phase
Recruiting NCT05111496 - Evaluation of the Radiological Dose Delivered to Risky Interventional Cardiology Patients (Optidose)
Not yet recruiting NCT05440084 - Impact of CTO PCI (Chronic Total Occlusion Percutaneous Intervention) on Regular Physical Activity
Withdrawn NCT04059536 - Registry Study to Evaluate the Performance and Safety of Roxwood Medical Catheters in Arteries of Participants With a Stenotic Lesion or Chronic Total Occlusion (CTO)
Completed NCT05158686 - Use of Drug-Coated Balloon to Improve Recanalization of a Coronary Chronic Total Occlusion After Failed Angioplasty
Completed NCT03988166 - Chronic Total Occlusion Percutaneous Coronary Intervention Study N/A
Not yet recruiting NCT06175377 - Antiplatelet Therapy After Successful Percutaneous Coronary Intervention for Chronically Occluded Coronary Artery N/A
Not yet recruiting NCT05632653 - CTO-PCI in Heart Failure Patients N/A
Recruiting NCT03563989 - STENTYS Xposition S in the Treatment of Chronic Total Artery Occlusion N/A
Recruiting NCT04710342 - Clinical Study Evaluating Use of the CapBuster Medical Device System for the Crossing of Chronic Total Occlusions N/A
Not yet recruiting NCT06358508 - Sapphire 3 CTO Study N/A
Completed NCT01246505 - Peripheral Facilitated Antegrade Steering Technique in Chronic Total Occlusions Phase 3
Recruiting NCT05614180 - Chronic Total Occlusive Lesions CMR Study
Recruiting NCT04533633 - German Epicardial Collateral CTO Registry
Recruiting NCT04650139 - Coronary Interventions Ulm - Coronary Chronic Total Occlusions
Recruiting NCT06137521 - Risk Factors and Outcomes in Coronary Chronic Total Occlusion
Completed NCT02358629 - A Prospective, Non-randomized Study to Evaluate the Safety and Performance of the NovaCross™ Microcatheter in Femoropopliteal Chronic Total Occlusion (CTO). N/A
Completed NCT00670436 - The Paclitaxel-Eluting Percutaneous Transluminal Coronary Angioplasty (PTCA) - Balloon Catheter in Coronary Artery Disease to Treat Chronic Total Occlusions Phase 2
Completed NCT04862559 - A Single Center Study to Evaluate the Safety of the NovaCross Microcatheter in Crossing Chronic Total Occlusions N/A
Active, not recruiting NCT02227771 - Consistent CTO Trial N/A
Recruiting NCT05458999 - Decreasing Patient Anxiety During Revascularization of Chronic Total Coronary Occlusions Using Virtual Reality Glasses. N/A