Esmolol vs. Labetalol in Endoscopic Sinus Surgery

Status Completed

Clinical Trial Summary

The purpose of this study is to compare esmolol and labetalol bleeding and intra-operative visibility scores in functional endoscopic sinus surgery.

Clinical Trial Description

BACKGROUND: Improved intraoperative visibility during functional endoscopic sinus surgery (FESS) decreases the risk of serious orbital or skull base injuries. Beta blockers are among several methods used to reduce mean arterial pressure (MAP), heart rate (HR) and mucosal bleeding. Labetalol (mixed alpha-1-beta blocker) reduces HR and MAP; however, its alpha-1 blockade may mitigate topical epinephrine decongestant effects. Esmolol (selective beta-1 blocker) does not have direct antagonistic effects on topical epinephrine. This study compares the hemodynamic parameters (rate of blood loss, MAP control, HR) and intraoperative visibility during FESS between esmolol and labetalol. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03661346
Study type	Interventional
Source	The University of Texas Medical Branch, Galveston
Contact
Status	Completed
Phase	Phase 2
Start date	March 1, 2017
Completion date	March 30, 2018

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