Chronic Sinusitis Clinical Trial
Official title:
Efficacy and Complication of Gentamicin Nasal Irrigation in Chronic Rhinosinusitis
The propose of this study to determine efficacy and complication of gentamicin nasal irrigation in chronic rhinosinusitis
Chronic rhinosinusitis (CRS) is characterized by symptoms > 12 weeks
Two or more symptoms one of which should be either nasal blockage /obstruction/congestion or
nasal discharge (anterior/posterior nasal drip):
- facial pain/pressure
- reduction or loss of smell)
Mainstay of treatment are medical and surgical treatment ( ATB, adenoidectomy, ESS)
Adjunctive treatment : normal saline nasal irrigation, nasal corticosteroids, nasal
decongestants, mucolytics Topical antibiotic therapy in patients with refractory sinusitis
has been shown to improve symptoms, quality of life, and mucosal aspect Nasal lavage with
Mupirocin represent an effective and well tolerated alternative treatment of surgically
recalcitrant chronic rhinosinusitis
In pediatrics allergy clinic at Siriraj hospital since 2006 use Gentamicin nasal irrigation
for chronic rhinosinusitis.There have been no studies in gentamicin irrigation in chronic
rhinosinusitis. The aims of this study are to evaluate:
1. Efficacy of gentamicin nasal irrigation in chronic rhinosinusitis (outcomes: frequency
of sinusitis, frequency of antibiotic usage)
2. Complication of gentamicin nasal irrigation usage
;
Observational Model: Case-Only, Time Perspective: Retrospective
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