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Chronic Sinusitis clinical trials

View clinical trials related to Chronic Sinusitis.

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NCT ID: NCT06398899 Not yet recruiting - Clinical trials for Head and Neck Neoplasms

Sugammadex v.s. Neostigmine/Glycopyrrolate

Start date: May 1, 2024
Phase: N/A
Study type: Interventional

The aim of study is to clarify the role of sugammadex in head and neck surgery patients with a prior history of urinary retention, benign prostatic hypertrophy, or a history of prostate cancer, to prevent postoperative urinary retention. The main question it aims to answer are: - Anticholinergic agent interferes the postoperative urination - Sugammadex does not interfere postoperative urination Sugammadex can be recommended for these patients with high risk in postoperative urinary retention in the future.

NCT ID: NCT06272123 Recruiting - Chronic Sinusitis Clinical Trials

Endotypic Stability in CRS

Start date: January 1, 2024
Phase:
Study type: Observational

A Case control study with 150 cases and 50 controls will be conducted. Immunologic (cytokines measurements in nasal secretions and sinonasal tissues), histopathologic (tissue eosinophilia) and clinical parameters (Lund-Mackay and Lund-Kennedy score, lung function tests), surveys (SNOT- 22, SF-36 quality of life survey) will be compared between different groups of patients

NCT ID: NCT06198894 Recruiting - Chronic Sinusitis Clinical Trials

Steroid-eluting Sinus Stent for Chronic Rhinosinusitis Patients With Uncontrolled Postoperative Symptoms

Start date: January 10, 2024
Phase: N/A
Study type: Interventional

Stent-001 study is a randomized controlled clinical trial with the steroid-eluting Sinus in 96 chronic rhinosinusitis patients with uncontrolled postoperative symptoms

NCT ID: NCT06070311 Not yet recruiting - Nasal Polyps Clinical Trials

Wound Healing After Endoscopic Sinus Surgery

Start date: October 2023
Phase: N/A
Study type: Interventional

This study aims to determine the effect of Thymoquinone (0.5%) and olive oil ointment on Wound healing after Endoscopic sinus surgery.

NCT ID: NCT06036927 Recruiting - Nasal Polyps Clinical Trials

A Clinical Study of TQC2731 Injection in the Treatment of Chronic Rhinosinusitis With Nasal Polyps

Start date: December 8, 2023
Phase: Phase 2
Study type: Interventional

This is a multicenter, randomized, double-blind, placebo-controlled Phase II clinical trial to evaluate the efficacy, safety and pharmacokinetics of TQC2731 injection in the treatment of Chronic Sinusitis with Nasal Polyps.

NCT ID: NCT06020690 Recruiting - Chronic Sinusitis Clinical Trials

A Clinical Study to Evaluate the Safety and Effectiveness of Novabel Bioabsorbable Steroid-releasing Stent for the Chronic Sinusitis

Start date: August 25, 2023
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to learn about the safety and effectiveness of Novabel bioabsorbable steroid-releasing stent in chronic sinusitis. The main questions it aims to answer are: - The safety of this device for the chronic sinusitis - The effectiveness of this device for the chronic sinusitis Participants will be implanted bioabsorbable steroid-releasing stents after FESS surgery. Participants will be asked to be back to the clinic for follow-up 14 days, 30 days, 90 days, 180 days and 360 days after procedure. Researchers will compare test device and marketed device to see if the safety and effectiveness between these two devices are non-inferior.

NCT ID: NCT05983003 Completed - Surgery Clinical Trials

Research on Identifying and Treatment Prognosis of Chronic Rhinosinusitis Based on Image and Sequencing Data

Start date: March 2015
Phase:
Study type: Observational

This project focuses on researching chronic rhinosinusitis in patients, employing image processing techniques and molecular biology methods to jointly determine the research objectives: 1. Investigating heterogeneity. 2. Developing an intelligent assessment model. 3. Creating a visual tool for diagnosis and prognosis.

NCT ID: NCT05454163 Not yet recruiting - Pediatric Cancer Clinical Trials

Post-radiotherapy Rhinosinusitis in Children

PRRSC
Start date: October 2022
Phase:
Study type: Observational

Chronic rhinosinusitis (CRS) is a frequent complication of facial cancer treatment, mainly related to radiotherapy. However, while radiological involvement is frequent, clinical expression seems less important. Few studies have investigated the incidence of this condition in the pediatric population while its evolution seems to be very chronic even if a partial improvement may occur with time. Our objective is therefore to study the impact of CSR in children treated for cancer of the cervicofacial region, to evaluate its incidence and medium-term evolution in order to determine whether it is necessary to set up a specific follow-up in these patients. The clinical impact of CSR is assessed by a specific SNOT 22 questionnaire in children treated for a head-neck mesenchymal malignancy in comparison with a control population consisting of children treated for a mesenchymal malignancy of non-head-neck location.

NCT ID: NCT05369039 Not yet recruiting - Chronic Sinusitis Clinical Trials

Roflumilust in Chronic Rhinosinusitis With Nasal Polyposis.

Start date: June 2022
Phase: Phase 2
Study type: Interventional

The current study will be a pilot study for a randomized controlled trial conducted on 60 patients recruited from the outpatient clinic of the Otorhinolaryngology Department, Menoufia Faculty of Medicine after approval of the institutional review board and taking informed written consent from every patient before participation in the study. The patients of this study will be randomly and equally distributed among case and control groups to compare the effect of Roflumilust administration with the effect of systemic and local corticosteroids on patients with chronic rhinosinusitis with nasal polyposis

NCT ID: NCT05295459 Recruiting - Chronic Sinusitis Clinical Trials

Efficacy and Safety of LYR-210 for the Treatment of Chronic Rhinosinusitis in Adults (ENLIGHTEN 2)

Start date: May 13, 2022
Phase: Phase 3
Study type: Interventional

Multicenter, phase III, randomized, blinded, controlled, parallel group.