Chronic Rhinosinusitis Clinical Trial
The investigators will conduct a descriptive, prospective, three-armed study concerning the
pathophysiology of chronic rhinosinusitis.
In one part of the study the investigators want to investigate the presence of biofilm in
patients with chronic rhinosinusitis both with and without nasal polyps compared with a
control group of subjects without chronic rhinosinusitis. The investigators will also
compare quality of life in the three groups and correlate disease severity in biofilm
patients versus patients where biofilm was not present.
The hypothesis here is that biofilm patients suffers a more severe disease.
In the other arm of the study the investigators will compare the presence of different
biochemical compounds in the three study groups. The investigators specifically want to
investigate matrix metalloproteases and apoptosis-inhibitors with immunohistochemistry. The
investigators may also add other compounds to our test-battery if interesting candidates
surface in the literature during the inclusion period.
The purpose of this part of the study is to investigate candidates for the development of
nasal polyposis.
The investigators plan to include 100 patients suffering from chronic rhinosinusitis with
nasal polyps, and 100 patients with chronic rhinosinusitis without nasal polyps and 30
control subjects.
n/a
Observational Model: Case Control, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
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||
| Completed |
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Large Scale Cerebral Oximetry During Sinus Endoscopy
|
N/A | |
| Completed |
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|
Phase 3 | |
| Completed |
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N/A | |
| Completed |
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|
Phase 2 | |
| Completed |
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Study Evaluating the Efficacy and Safety of Intranasal Administration of OPN-375 in Subjects With Chronic Rhinosinusitis With or Without the Presence of Nasal Polyps
|
Phase 3 | |
| Completed |
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Influence of Oral Doxycycline on Wound Healing After Endonasal Endoscopic Sinus Surgery for Chronic Rhinosinusitis With and Without Nasal Polyposis: a Double-blind Randomized Placebo-controlled Trial
|
Phase 2 | |
| Active, not recruiting |
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|
Phase 1/Phase 2 | |
| Completed |
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A Clinical Trial of Omalizumab in Participants With Chronic Rhinosinusitus With Nasal Polyps
|
Phase 3 | |
| Terminated |
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|
Phase 2/Phase 3 | |
| Completed |
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|
Phase 4 | |
| Completed |
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The Use of Antibiotic Sinonasal Rinse After Sinus Surgery
|
Phase 4 | |
| Recruiting |
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Effect of Sinufoam-Dexamethasone Mixture on Post Endoscopic Sinus Surgery Outcomes
|
Phase 4 | |
| Completed |
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Effect of Prednisone onTregs and TH17
|
Phase 1 | |
| Completed |
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|
Phase 4 | |
| Completed |
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A Clinical Trial of Omalizumab in Participants With Chronic Rhinosinusitis With Nasal Polyps
|
Phase 3 | |
| Recruiting |
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||
| Completed |
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|
Phase 3 | |
| Completed |
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N/A | |
| Completed |
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N/A |