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The Effect of Oral Guaifenesin on Pediatric Chronic Rhinitis: A Pilot Study

Chronic Rhinitis Clinical Trial

Official title:
The Effect of Oral Guaifenesin on Pediatric Chronic Rhinitis: A Pilot Study

Clinical Trial Summary

This is a 14-day, randomized, placebo-controlled, parallel group, masked clinical trial of oral guaifenesin for the therapy of Chronic Rhinitis (CRS) in 36 children between the ages of 7 and 18 years. The study investigates the effectiveness of guaifenesin in the relief of nasal symptoms in children with CRS using the sinonasal 5 survey (SN-5) in comparison to nasal airway volume, and biophysical properties of nasal secretion. The investigators hypothesize that Guaifenesin use over a period of 14 days improves subjective nasal complaints in pediatric patients with chronic rhinitis and nasal congestion, as measured by the SN-5 survey compared to use of placebo. There will be an observed improvement in nasal volume and cross-sectional area following use of guaifenesin, and nasal secretions will have more favorable mucociliary and sneeze clearability compared to use of placebo.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01364467
Study type Interventional
Source Virginia Commonwealth University
Contact
Status Completed
Phase Phase 2
Start date May 2011
Completion date March 5, 2018
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