Chronic Respiratory Disease Clinical Trial
— EPAR-APCOfficial title:
Pharmacological Evaluation of Antifungal Drugs in Respiratory Samples of Patiens With Chronic Pulmonary Aspergillosis
NCT number | NCT05064605 |
Other study ID # | APHP211257 |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | October 1, 2021 |
Est. completion date | October 1, 2024 |
At present, pulmonary diffusion and target antifungal concentrations for APC in patients with sarcoidosis or chronic obstructive pulmonary disease (COPD) are unknown.
Status | Recruiting |
Enrollment | 50 |
Est. completion date | October 1, 2024 |
Est. primary completion date | October 1, 2022 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Patient over 18 years of age - Diagnosis of PCA made according to the criteria of Denning et al. Eur Respir J. 2016 - Previously initiated or newly initiated azole antifungal therapy for chronic lung disease complicated by CPA. - Informed patients who did not object to the use of their data. Exclusion Criteria: - Pregnant woman - Co-medication affecting the pharmacokinetics of antifungal agents: Enzyme inducing therapy (rifampin, rifabutin, phenytoin, phenobarbital, efavirenz, nevirapine, etravirine, ritonavir in the case of voriconazole) Drugs that may inhibit the metabolism of antifungal drugs (ritonavir and cobicistat for itraconazole and isavuconazole) - Patients under guardianship/guardianship - Patients without social security coverage |
Country | Name | City | State |
---|---|---|---|
France | Hôpital Avicenne | Bobigny |
Lead Sponsor | Collaborator |
---|---|
Assistance Publique - Hôpitaux de Paris |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Ratio of antifungal concentrations in lung samples/plasma samples depending on the type of lung sample (sputum, bronchial aspiration, bronchoalveolar lavage fluid) | Ratio of antifungal concentrations in lung samples/plasma samples depending on the type of lung sample | At 12 months |
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