Clinical Trials Logo
  1. Home
  2. Chronic Respiratory Disease
  3. NCT03153800

Autologous Bronchial Basal Cells Transplantation for Treatment of CRD Including COPD, BE and PF

Chronic Respiratory Disease Clinical Trial

Official title:
Autologous Bronchial Basal Cells Transplantation for Treatment of Chronic Respiratory Disease (CRD) Including Chronic Obstructive Pulmonary Disease (COPD), Bronchiectasis (BE) and Pulmonary Fibrosis (PF)

Clinical Trial Summary

Chronic respiratory diseases including chronic obstructive pulmonary disease (COPD), bronchiectasis (BE) or pulmonary fibrosis (PF) are usually not curable with damaged pulmonary structure and function. Bronchial basal cells are proved to regenerate bronchus and alveoli to repair the pulmonary injuries. In this study, we intend to perform an open, single-armed phase I clinical trial by transplantation of autologous bronchial basal cells on patients suffered from COPD, BE or PF. During the treatment, autologous bronchial basal cells, which were isolated from fiberoptic bronchoscopy and expanded in vitro, will be injected directly into lesions by fiberoptic bronchoscopy after careful characterization. In the following 6 months, the safety and efficacy of the treatment will be monitored by measuring the key clinical indicators.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03153800
Study type Interventional
Source Regend Therapeutics
Contact Wei Zuo, Ph. D.
Phone 086-400-882-1090
Email zuow@regend.cn
Status Recruiting
Phase Early Phase 1
Start date April 5, 2017
Completion date October 4, 2021
View Details
See also
  Status Clinical Trial Phase
Completed NCT02894190 - Development and Validation of the BVQ
Recruiting NCT04566523 - TeleRehabilitation for Patients With Chronic Respiratory Failure.
Recruiting NCT04139356 - The Effect of Spontaneous Respiration on Pulse-oximetry Measurements N/A
Completed NCT03880630 - Inspiratory Muscle Activation Pattern Analysis in Assisting Precision in Inspiratory Muscle Training in Patients With Chronic Respiratory Disease N/A
Completed NCT03728595 - Validation of a Predictive Score for HAST
Completed NCT03294057 - Collaborative Care With Smart Health Management Program for Patients With Chronic Illness N/A
Completed NCT03704935 - Long Term Effects and of a Pulmonary Rehabilitation Maintenance Program
Recruiting NCT05064605 - Pharmacological Evaluation of Antifungal in Chronic Pulmonary Aspergillosis
Recruiting NCT06149494 - RCT of Vapendavir in Patients With COPD and Human Rhinovirus/Enterovirus Upper Respiratory Infection Phase 2
Recruiting NCT03797183 - Genesis Electrical Impedance Tomography (EIT): A Preliminary Study
Enrolling by invitation NCT05724082 - The Effect of Household Air Pollution on Lung Function Growth in Infants With Pneumonia in Sub-Saharan Africa N/A
Completed NCT04623762 - Yoga On Dyspnea, Sleep And Fatıgue In Chronıc Respıratory Dıseases N/A
Not yet recruiting NCT06321471 - AeviceMD for Pediatric Asthma Management N/A
Not yet recruiting NCT06459011 - Shedding Light on a Forgotten Workforce: Loved Ones of People With Chronic Respiratory Diseases
Recruiting NCT05248412 - The Long-term Spill-over Impact of COVID-19 on Health and Healthcare of People With Non-communicable Diseases
Not yet recruiting NCT04911764 - Three-min Step Test and Exercise Desaturation Detection in Chronic Respiratory Insufficiency Patients N/A
Completed NCT02715219 - The Effect of an AEP on Patient's Knowledge Regarding Asthma Disease and Inhaler Technique: RCT N/A
Completed NCT03799666 - (Re)Vitalizing Pulmonary Rehabilitation for Patients With Chronic Respiratory Diseases N/A
Completed NCT03188588 - Observance of Long Term Oxygen Therapy in Chronic Inspiratory Disease Patients
Completed NCT03930511 - Telemonitoring Physical Activity in Daily Life on Chronic Respiratory Patients N/A