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Chronic Rejection clinical trials

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NCT ID: NCT01052259 Terminated - Chronic Rejection Clinical Trials

Efficacy and Safety of Deoxyspergualin in Renal Transplant Patient With Chronic Rejection

Start date: June 2009
Phase: N/A
Study type: Interventional

The purpose of this study to examine the efficacy and safety of cycling treatment of deoxyspergualin in renal transplant patients with biopsy-proven chronic rejection.

NCT ID: NCT00980967 Active, not recruiting - Clinical trials for Lung Transplantation

Predictive Factors for Chronic Rejection in Lung Transplant Recipients: COLT Study

COLT
Start date: September 2009
Phase: N/A
Study type: Interventional

Obliterative Bronchiolitis (OB) is the major cause of long-term lung allograft loss for patients with end stage pulmonary diseases like cystic fibrosis. Numerous cells and proteins are implicated in this process, which have never been studied prospectively in a multicentric longitudinal cohort. The aim of this study is to detect predictive risk factors of OB through a national multicentric cohort of 500 newly transplanted recipients (COLT). COLT will consist in a large database, associated with a recipient bio-collection, and specific projects using these resources. COLT will aggregate all the 11 French centres of pulmonary transplantation. Patient will be followed-up during 5 years. Blood samples will be obtained. Induced sputum, bronchoalveolar lavage fuid, exhaled breath condensate and trans bronchial biopsies will be also taken. T cells, known to be involved in chronic rejection will be studied, and genomic, microarray and proteomic approaches will be used to detect further predictive factors. A study on Circulating Endothelial Cells and Circulating Endothelial Progenitors is also realised from blood samples. COLT will prove molecular markers to be predictive of early OB, before the development of severe airway obstruction and will allow the identification of patients at high risk of OB. COLT will identify potential targets for future treatments of OB. This collaborative project makes research and clinical teams working together, and creates the conditions of a long term network, extendable to other laboratories with new projects and additional European transplant centres.

NCT ID: NCT00283348 Completed - Chronic Rejection Clinical Trials

New Strategies for Non-invasive Detection of Chronic Allograft Nephropathy

Start date: January 2006
Phase: N/A
Study type: Observational

The purpose of this study is to help researchers find out more about a condition called "Chronic Allograft Nephropathy" (CAN). CAN is a complication that sometimes occurs after kidney transplantation and affects the function of the transplanted kidney. It is hoped that by studying blood, urine, and tissue samples of kidney transplant patients, new ways of diagnosing and treating CAN may be found.

NCT ID: NCT00261547 Withdrawn - Clinical trials for Kidney Insufficiency

Rituximab Treatment to Block HLA Antibodies in Renal Transplant Recipients

Start date: December 2005
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to determine if administration of rituximab blocks the development of donor specific antibodies (DSA) in transplant recipients who have developed renal dysfunction and DSA after renal transplant. It is hoped that by blocking DSA production renal function will stabilize or improve.