Chronic Polypous Rhinosinusitis Clinical Trial
Official title:
The Role of Nanoparticles in Inflammatory Changes of the Nasal Mucosa
The aim of this prospective study is to evaluate presence and quantity of nano-sized particles and interindividual differences in their distribution and elemental composition in human nasal mucosa obtained by mucotomy in patients diagnosed with chronic hypertrophic rhinosinusitis and to compare the obtained results with control specimen obtained from stillborn children.
Samples of nasal mucosa are obtained by mucotomy in general anesthaesia from adult patients
with chronic hypertrophic rhinosinusitis. Each tissue sample is divided into 4 parts based on
the distance from the nostrils and is dehydrated, thinly sliced and mounted on glass slides.
Then the tissue is analyzed with scanning electron microscopy (SEM) and Raman
microspectroscopy (RMS) to detect solid particles and characterize the morphology and
compositions of the detected particles. A novel method of quantification of distribution of
the particles has been designed and used to evaluate interindividual differences in
distribution of the particles. History of employment is obtained from the patients and the
data are compared with the findings in the tissue samples.
The data acquired from the group of adult patients are compared with the results obtained
from a group of control specimen of nasal mucosa harvested from stillborn children. It is
presumed that no nano particles will be present in the stillborn children specimen since the
mucosa was not exposed to airborne particles.
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04472689 -
Effects of Lidocaine Infusion on Quality of Recovery and Agitation After Functional Endoscopic Sinus Surgery
|
N/A |