Chronic Peritonitis Clinical Trial
Official title:
Effects of Vitamin D on Chronic Periodontitis
The object of the study was to evaluate the direct effect of high dose vitamin D supplementation on chronic periodontitis, and suggest the recommended dose for clinic use.
Periodontitis is a chronic inflammatory disease characterized by periodontal tissues
inflammation and alveolar bone loss. Vitamin D is involved in stimulating osteoblasts to
enable normal bone growth and preservation, also the regulation of cellular proliferation,
differentiation, innate immune response and anti-inflammatory effect.Previous studies have
reported the association of vitamin D levels and gingivitis and periodontitis. This study was
designed as a randomized controlled trial to evaluate the effect of vitamin D supplementation
on chronic periodontitis.
The study was divided into two phases. Recruitment including baseline clinical measurements
was obtained and standard periodontal treatments were performed in Phase One. The
randomization and intervention of vitamin D were performed in Phase Two. The 323 subjects
were randomly divided into 3 groups (n=105,110,108) to receive a supplement kit containing 90
capsules of 2000 IU vitamin D, 1000 IU vitamin D, or placebo capsule for 3 months. After
intervention, all the subjects were followed up after 3 months and received standard
periodontal examination, including attachment loss (AL), probing depth (PD), bleeding index
(BI), and panoramic radiographs were taken to evaluate alveolar crest height (ACH).
;