Injectable Platelet Rich Fibrin With Non Surgical Periodontal Therapy

Status Not yet recruiting

Clinical Trial Summary

Clinical evaluation of local subgingival application of injectable platelet-rich fibrin ( i-PRF ) for chronic periodntitis as adjunctive to non surgical therapy and compare it with hyaluronic acid.

120 periodontal patients will receive a scaling and root planing ( non surgical periodontal therapy). Equal number of patients will receive subgingival application of i-PRF, hyaluronic acid or placebo gel as the adjunction to non surgical therapy.

Clinical Trial Description

The aim of the study is to evaluate and compare the clinical efficacy of subgingival application of i-PRF and hyaluronic acid gel as adjunctive to non-surgical periodontal therapy. 120 periodontal patients will receive traditional mechanical supra and subgingival scaling and root planing. Patients were randomly allocated in three groups. Group 1, 2 and 3 will receive subginigval application of placebo, hyaluronic acid gel and i prf respectively. Clinical parameters will be evaluated: plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing depth (PD), clinical attachment level (CAL), gingival recession (GR). Clinical measurements will be performed at baseline, 1 month and at 3 months. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04070729
Study type	Interventional
Source	Institute of Dental Sciences, Bareilly, Uttar Pradesh, India
Contact
Status	Not yet recruiting
Phase	N/A
Start date	August 28, 2019
Completion date	January 25, 2020

View Details

See also
Status	Clinical Trial	Phase
Not yet recruiting	`NCT06400069` - Role of NLRP6 in Chronic Periodontitis
Completed	`NCT05231096` - Comparison of the Effect of Gingival Massage of Aloe-vera Gel and Sidr Honey on Chronic Periodontitis	N/A
Completed	`NCT03203746` - Gingival Crevicular Fluid Levels of Protein Carbonyl Following the Use of Lycopene in Chronic Periodontitis	Phase 1/Phase 2
Active, not recruiting	`NCT03354338` - Amoxicillin to Prevent Bacteria and Inflammatory Biomarkers After Intensive Periodontal Therapy	Phase 2
Completed	`NCT02516111` - Comparison of Autologous PRF, 1% Alendronate and 1.2% Atorvastatin Gel in Chronic Periodontitis Treatment	Phase 2/Phase 3
Terminated	`NCT02568163` - Influence of Stress on Non Surgical Periodontal Treatment	N/A
Completed	`NCT02174146` - Leptin and Visfatin in Diabetic Patients With Periodontitis Before and After Periodontal Therapy	N/A
Completed	`NCT02430519` - Benefits of Platelet Rich Fibrin In Mandibular Molar Furcation Defects	N/A
Completed	`NCT01438333` - Efficacy of INERSAN in Patients With Chronic Periodontitis as Adjunctive to Full Mouth Disinfection	N/A
Completed	`NCT01233765` - Analysis of Neutrophil Response in Chronic Periodontitis	N/A
Completed	`NCT02218515` - Treatment of Intrabony Periodontal Defects With Enamel Matrix Derivatives and Autogenous Bone Graft	Phase 4
Completed	`NCT02197260` - Antimicrobial Therapy as Adjunct to Periodontal Treatment: Effect of Timing	Phase 4
Not yet recruiting	`NCT03270280` - Comparison of Salivary Interleukin-1β and Matrix Metalloproteinase-8 Levels in Individuals With Chronic Periodontitis	Phase 2
Not yet recruiting	`NCT04026828` - Evaluation of Possible Genes in Periodontal Diseases by Genetic Methods
Completed	`NCT04697199` - The Adjunctive Effect of Probiotics to Non Surgical Treatment of Chronic Periodontitis	Phase 1
Completed	`NCT04643288` - Nanocrystalline Hydroxyapatite Bone Substitute for Treating Periodontal Intrabony Defects	N/A
Completed	`NCT03039244` - Evaluation of Antimicrobial Photodynamic Therapy as an Adjunct to Periodontal Treatment in Smokers	N/A
Completed	`NCT02898675` - Advantages of Autologous Platelet-Rich Fibrin Membrane on Growth Factor Levels and Periodontal Healing	N/A
Completed	`NCT02518152` - Platelet Rich Fibrin+1% Alendronate in Treatment of Chronic Periodontitis	Phase 2/Phase 3
Completed	`NCT03874390` - Effects of Ozone Therapy on Clinical Parameters and Inflammatory Cytokines in Chronic Periodontitis Patients	N/A