Chronic Periodontitis Clinical Trial
Official title:
Evaluation of Possible Genes in Periodontal Diseases by Genetic Methods
Generalized aggressive Periodontitis (GAgP) and chronic periodontitis (CP) are inflammatory
diseases. Little is known about molecular changes and signaling cascade of host response.
Inflammatory diseases are undercontrol of genetic and enviromental factors. Transcription
factors are gene-specific factors that are often considered to act as a link connecting
genetic and enviromental factors.
The aim of this study is to investigate the gene regions that are thought to play a role in
the pathogenesis of GAgP and CP, and to interpret new and reliable pathognomonic-prognostic
markers in the diagnosis and treatment of these diseases with the help of expression and
mutation analyzes and polymorphism studies.
Status | Not yet recruiting |
Enrollment | 200 |
Est. completion date | July 15, 2022 |
Est. primary completion date | August 31, 2021 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | N/A and older |
Eligibility |
Inclusion criteria for aggressive periodontitis patients; - The periodontal diagnosis of subjects with GAgP was established on the basis of clinical and radiographic criteria and was defined by the 1999 International World Workshop for a Classification of Periodontal Diseases and Conditions (Lang et al., 1999), - Between 18 and 35 years of age, - Otherwise healthy, - The bone loss estimation was radiographically performed in each patient for the assessment of the extent and severity of alveolar bone loss. Inclusion criteri for chronic periodontitis patients; - Had at least 20 teeth, - Exhibiting >30% of measured sites with 5mm clinical attachment loss,, - Had bleeding on probing (BOP) at >50% of the proximal sites. Inclusion criteri for control individuals; - Overall healthy individuals (dental, periodontal and systemically) Exclusion Criteria for all individuals; - Had any known systemic diseases or conditions that can/could influence the periodontal status (cancer, cardiovascular and respiratory diseases), - Any history of hepatitis and/or HIV infection, - Immunosuppressive chemotherapy, - Current pregnancy, planning a pregnancy or lactation, - Requirement for antibiotic prophylaxis, - Had oral diseases other than GAgP, - Oongoing orthodontic therapy, - A history of antibiotic therapy, or periodontal treatment within the preceding six months |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Kocaeli University |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Quality and accuracy of the products of RNA and DNA | RNA and DNA will be isolated from cells and the quality and accuracy of the products will be tested by Agilent 2100 bioanalyzer chips and quatity of the products will be controlled by Nanodrop ND 1000 spectrophotometer. | 6 months | |
Primary | Mutations Analysis | Evaluation will be performed with DNA which extracted from tissues. Amplicons will be reproduced by multiplex PCR, analysed by Ion reporter and the outcomes will be evaluated with diverse online databases and clinical correlations. | 6 Months | |
Primary | Gene polymorphism | Genes will evaluated by LightSNiPs | 6 Months |
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