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The Effect of Zinc on the Gingival Crevicular Fluid Level of Total Oxidant Capacity in Type 2 Diabetic Patients

Chronic Periodontitis Clinical Trial

Official title:
The Effect of Systemic Administration of Zinc on the Gingival Crevicular Fluid Level of Total Oxidant Capacity in Type 2 Diabetic Patients With Stage II and III Periodontitis After Non-surgical Periodontal Therapy

Clinical Trial Summary

To evaluate the effect of systemic administration of zinc on the gingival crevicular fluid level of total oxidant capacity in controlled Type-2 diabetic patients with stage-II and III periodontitis after non-surgical periodontal therapy.

Clinical Trial Description

Hypozincaemia and hyperzincuria is known to be present in patients with type-2 diabetes, and Zinc supplementation is known to be helpful in restoring plasma Zinc levels to normal,Zinc's deficiency can lead to an increase in circulating glucose due to beta cells malfunctioning and resistance to insulin, which makes it easier for type 2 diabetes mellitus (DM2) to happen ,Zinc was found to be a structural part of key anti-oxidant enzymes such as superoxide dismutase (SOD), and Zinc deficiency impaired their synthesis, leading to increased oxidative stress ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03923829
Study type Interventional
Source Cairo University
Contact abdulrahman A Abdulrab
Phone +201014624724
Email abdulrahman.awadh@dentistry.cu.edu.eg
Status Not yet recruiting
Phase N/A
Start date April 30, 2019
Completion date August 30, 2020
View Details
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