Chronic Periodontitis Clinical Trial
Official title:
Preparation and Analysis of Material, Biological and Clinical Parameters of Metronidazole-loaded Porous Matrices for Local Periodontitis Treatment
Aim of the study is the efficiency assessment of porous Metronidazole loaded matrix based on
gelatin/hydroxyethylcellulose blend in treatment of deep periodontal pockets resulting from
severe chronic periodontitis. The matrix was invented and produced in Department of Drug Form
Technology, Wroclaw Medical University.
The porous metronidazole (MTZ) loaded matrix was fabricated by the freeze-drying technique.
The morphology, mechanical properties, in vitro degradation, MTZ release from dried sponge
were evaluated and also the clinical trials were performed.
Patients suffering from chronic periodontitis are examined. To evaluate oral hygiene API
(Approximal Plaque Index) and the gum inflammation BOP (Bleeding on Probing) and PBI (Papilla
Bleeding Index) indices are used. The clinical examination is performed 3 times. On the first
visit the output indicators are defined. The subgingival scaling is performed and
Metronidazol on porous matrix is applied to the selected periodontal pockets. 2 control tests
of periodontal indices are carried out after one week and one month from the application.
In the control group after scaling/root planing procedure, there is no application of
metronidazole.
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