Chronic Periodontitis Clinical Trial
Official title:
COMPARATIVE EVALUATION OF SUBGINGIVALLY DELIVERED 1% METFORMIN AND ALOE VERA GEL IN TREATMENT OF INTRABODY DEFECTS IN CHRONIC PERIODONTITIS SUBJECTS: A RANDOMIZED CONTROLLED CLINICAL TRIAL
Metformin (MF), a biguanide group of anti-diabetic drug has been shown to enhance
osteoblasts differentiation and inhibit osteoclast differentiation in vitro, thus may
exhibit a favorable effect on alveolar bone.
AloeVera Gel had also been used in dentistry and showed good results.The present study aims
to explore the efficacy of 1% MF gel and aloe vera gel as a local drug delivery system in
adjunct to scaling and root planing (SRP) for the treatment of subjects with chronic
periodontitis (CP) with intrabody defects.
Aim: To compare the efficacy of locally delivered 1% MF gel and aloe vera gel in treatment
of intrabony defects in chronic periodontitis subjects and compare it with placebo gel.
Methods: Ninety subjects were categorized into three treatment groups: Placebo, aloevera
gel(AV) and 1% Metformin (MF)after Scaling and root planning (SRP). Clinical parameters were
recorded at baseline, 6 and 12 months; they included plaque index (PI), modified sulcus
bleeding index (mSBI), pocket probing depth (PPD), and clinical attachment level (CAL).
Radiologic assessment of intra-bony defect (IBD) and percentage defect depth reduction
(DDR%) was done at baseline, 6 months and 12 months interval using computer-aided software
Results: Mean PPD reduction and mean CAL gain was found to greater in MF group than AV and
placebo group at all visits. The DDR% was greater in MF group as compared to AV and placebo
group.
Conclusion: There was a greater decrease in mSBI and PPD and more CAL gain at the sites
treated with AV and MF as an adjunct to SRP in chronic periodontitis subjects with intrabony
defects as compared to placebo. The significant IBD depth reduction effect was seen in case
of MFgroup.
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