Chronic Periodontitis Clinical Trial
Official title:
Comparative Evaluation of Locally Delivered 1% Metformin and 1.2% Rosuvastatin Gel in Treatment of Intrabony Defects in Chronic Periodontitis Subjects: A Randomized Controlled Clinical Trial
Metformin (MF), a biguanide group of anti-diabetic drug has been shown to enhance osteoblasts differentiation and inhibit osteoclast differentiation in vitro, thus may exhibit a favourable effect on alveolar bone. Statins are one of the lipid lowering drugs that help in reducing cholesterol levels in the body by specifically inhibiting 3-hydroxy-3-methylglutaryl coenzyme A reductase; which is a rate limiting enzyme for cholesterol synthesis. Rosuvastatin (RSV) have shown to have bone stimulatory and anti-inflammatory effects.Statins are one of the lipid lowering drugs that help in reducing cholesterol levels in the body by specifically inhibiting 3-hydroxy-3-methylglutaryl coenzyme A reductase; which is a rate limiting enzyme for cholesterol synthesis. Rosuvastatin (RSV) and atorvastatin (ATV) have shown to have bone stimulatory and anti-inflammatory effects.. The present study aims to explore the efficacy of 1.2% RSV and 1MF gel as a local drug delivery and redelivery system as an adjunct to scaling and root planing (SRP) for the treatment of intrabony defects.
Metformin (MF), a biguanide group of anti-diabetic drug has been shown to enhance
osteoblasts differentiation and inhibit osteoclast differentiation in vitro, thus may
exhibit a favourable effect on alveolar bone. Statins are one of the lipid lowering drugs
that help in reducing cholesterol levels in the body by specifically inhibiting
3-hydroxy-3-methylglutaryl coenzyme A reductase; which is a rate limiting enzyme for
cholesterol synthesis. Rosuvastatin (RSV) have shown to have bone stimulatory and
anti-inflammatory effects.Statins are one of the lipid lowering drugs that help in reducing
cholesterol levels in the body by specifically inhibiting 3-hydroxy-3-methylglutaryl
coenzyme A reductase; which is a rate limiting enzyme for cholesterol synthesis.
Rosuvastatin (RSV) and atorvastatin (ATV) have shown to have bone stimulatory and
anti-inflammatory effects.. The present study aims to explore the efficacy of 1.2% RSV and
1MF gel as a local drug delivery and redelivery system as an adjunct to scaling and root
planing (SRP) for the treatment of intrabony defects.
Methods: Ninety patients with intrabony defects were randomly allocated into three treatment
groups: SRP plus placebo gel (group 1), SRP plus 1.2% RSV gel (group 2) and 1% MF gel
(group3). Clinical and radiographic parameters were recorded at baseline then after 6
months. The gels were delivered at the respective sites at baseline . Then again all
clinical and radiographic parameters were recorded after 6 months and 12 months.
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