Chronic Periodontitis Clinical Trial
Official title:
Gingival Crevicular Fluid Levels of Protein Carbonyl Oxidative Stress Biomarker Following the Use of Locally Delivered Lycopene Antioxidants in Patients With Chronic Periodontitis - Randomized Clinical Trial
Effect of Locally Delivered Antioxidants as An Adjunct to Non-surgical Periodontal Therapy on GCF Level of Oxidative Stress Marker; Protein Carbonyl
The study was designed as a randomized controlled clinical trial. Total subjects selected
were allocated into three study groups, Group I (Test group), Group II (Positive control
group) and Group III (Negative control group). Group I: Included 8 patients with severe
chronic periodontitis managed by Scaling and root planing and local delivery of lycopene
loaded in solid lipid microparticles. Group II: Included 8 patients with severe chronic
periodontitis managed by Scaling and root planing only. Group III: Included 8 patients with
clinically healthy periodontium.
Protein carbonyl biomarker level and clinical parameters were assisted to evaluate the
effect of lycopene as an adjunct to scaling and root planing.
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