Chronic Periodontitis Clinical Trial
Introduction- Oxidative stress plays a causative role in pathogenesis of periodontal
disease.
It has been reported that Spirulina platensis or its active ingredient C phycocyanin (CPC)
exerts anti-inflammatory, anti-oxidative and inhibitory effects on prostaglandin and
leukotriene biosynthesis.
Aim- To evaluate the effect of dietary spirulina as an adjunct to SRP on salivary
antioxidants level in CP subjects.
Materials And Methods- The study was a randomized double-blind clinical and biochemical
trial in which 70 subjects with CP in the age group of 40-55 years, reporting to Department
of Periodontology, TKDC and RC, New Pargaon, were equally and randomly divided into Test
Group (TG) and Control Group (CG). TG was given 2 gm Spirulina capsules daily, after meals
for 1 month and CG was not given any supplementary diet. SRP was done at baseline in TG and
CG. Whole saliva sample was collected. Clinical and biochemical parameters will be recorded
at baseline, 1 month & 3 months.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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