Combined Use of Er:YAG and Nd:YAG Laser

Chronic Periodontitis Clinical Trial

Official title:

Combined Application of ER:YAG and ND:YAG Lasers in Treatment of Chronic Periodontitis: A Split-mouth Randomized Controlled Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02851823
• Other study ID #: 114S767
• Status: Completed
• Phase: N/A
• First received: July 25, 2016
• Last updated: October 8, 2017
• Start date: October 2014
• Est. completion date: April 2016

Study information

• Verified date: October 2017
• Source: Izmir Katip Celebi University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of the present study was to compare the effectiveness of combined Er:YAG and Nd:YAG laser therapy to that of scaling and root planning with hand instruments in nonsurgical treatment of chronic periodontitis.

Description:

The aim of the present study was to compare the effectiveness of combined Er:YAG and Nd:YAG laser therapy to that of scaling and root planning with hand instruments in nonsurgical treatment of chronic periodontitis.Twenty-five systemically healthy patients with moderate-to-advanced periodontal destruction were selected for this study. The quadrants were randomly allocated in a split-mouth design to either combined Er:YAG (160 mj/pulse, and 10 Hz) and Nd:YAG laser (100 mJ/pulse, and 20 Hz) therapy (test group) or scaling root planning using hand instruments (control group). At baseline, 1 month, and 3 months after treatment, clinical measurements, including plaque index (PI), gingival index (GI), probing depth (PD), clinical attachment level (CAL), and bleeding on probing (%) (BOP), were performed and gingival crevicular fluid and subgingival plaque samples were taken. The gingival crevicular fluid levels of interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) were analyzed by enzyme-linked immunosorbent assay. Total antioxidant status (TAS)/total oxidant status (TOS) were analyzed by high-performance liquid chromatography and a novel automatic colorimetric method. Quantitative analysis of Porphyromonas gingivalis (Pg), Tannerella forsythia (Tf), and Treponema denticola (Td) was performed using real-time polymerase chain reaction (PCR) procedures.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 25
• Est. completion date: April 2016
• Est. primary completion date: October 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 19 Years to 70 Years

Eligibility

Inclusion Criteria:

• The patients had =4 teeth per quadrant with probing depth (PD) of =5 mm, clinical attachment level (CAL) of =4 mm, and radiographic signs of alveolar bone loss. These individuals also had bleeding on probing (BOP) at >80% of the proximal sites.

Exclusion Criteria:

• Periodontal treatment received for the last 1 year; systemic diseases that could influence the outcome of the therapy, pregnancy, smoking, immunosuppressive chemotherapy; and use of antibiotics and anti-inflammatory drugs for the last 6 months.

Related Conditions & MeSH terms

• Chronic Periodontitis
• Periodontitis

Intervention

Device:
• Periodontal curettes

• Er-YAG+Nd-YAG lasers

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
Izmir Katip Celebi University	Tubitak

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Clinical Attachment Level Change for Moderately Deep Pockets (4 mm=PD=6 mm)	Change in clinical attachment level for moderately deep pockets (4 mm=PD=6 mm) between baseline and 1 month Change in clinical attachment level for moderately deep pockets (4 mm=PD=6 mm) between baseline and 3 month	Baseline, 1 and 3 months
Primary	Clinical Attachment Level Change for Deep Pockets (7 mm=PD)	Change in clinical attachment level for deep pockets (7 mm=PD) between baseline and 1 month.; Change in clinical attachment level for deep pockets (7 mm=PD) between baseline and 3 month.	Baseline, 1 and 3 months