Chronic Periodontitis Clinical Trial
Official title:
Efficacy Of Platelet Rich Fibrin With 1% Alendronate For Treatment Of Intrabony Defects In Chronic Periodontitis: A Randomized Controlled Clinical Trial
The present study is designed to evaluate the combined efficacy of Platelet Rich Fibrin (PRF) and 1% Alendronate (ALN) with open flap debridement (OFD) in treatment of intrabony defects in chronic periodontitis patients.
Background: Platelet-rich fibrin (PRF) is a second-generation platelet concentrate, act as
reservoirs of growth factors and cytokines which are the key factors for regeneration of the
bone and maturation of the soft tissue. Alendronate (ALN), a potent member of bisphosphonate
group is known to promote tissue regeneration by inhibiting osteoclastic bone resorption and
promoting osteoblastogenesis. The present study was designed to evaluate the combined
efficacy of PRF and 1% ALN with open flap debridement (OFD) in treatment of intrabony
defects in chronic periodontitis patients.
Methods: Ninety patients with single defects were categorized into three groups: OFD alone,
OFD with PRF,OFD with PRF+1% ALN. Clinical parameters; site specific plaque index (PI),
modified sulcus bleeding index (mSBI), probing depth (PD), clinical attachment level (CAL)
and gingival marginal level (GML) were recorded at baseline before surgery and 9 months
post-operatively. Percentage radiographic intra-bony defect depth reduction (IBD) was
evaluated at baseline and 9 months.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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