Chronic Periodontitis Clinical Trial
Official title:
Comparative Evaluation of Autologous PRF, 1% Alendronate and 1.2% Atorvastatin Gel in Treatment of 2/3-walled Intrabony Defects in Chronic Periodontitis Subjects: a Randomized Controlled Clinical Trial
The present study is designed as a single-centre, randomized, controlled clinical trial to evaluate and compare the clinical efficacy of autologous PRF, 1% alendronate (ALN) and 1.2% atorvastatin (ATV) gel placement with open flap debriedement in treatment of intrabony defects in patients with chronic periodontitis.
Background: Platelet-rich fibrin (PRF) is a second-generation platelet concentrate which
releases various growth factors that promote tissue regeneration. Alendronate and
Atorvastatin are known to inhibit osteoclastic bone resorption and were proposed to have
osteostimulative properties by causing osteoblast differentiation in vivo and in vitro as
shown by an increase in matrix formation. The aim of the present study is to evaluate and
compare the efficacy of autologous PRF, 1% alendronate and 1.2% atorvastatin gel placement
with open flap debriedement in treatment of intrabony defects in patients with chronic
periodontitis.
Methods: 120 CP subjects with IBD ≥3 mm deep and probing depth (PD) ≥5 mm, following scaling
and root planing (SRP), were categorized into four treatment groups: 1) OFD 2) OFD with PRF
3) OFD with 1% ALN gel and 4) OFD with 1.2% ATV gel. Clinical parameters including site
specific plaque index (PI), modified sulcus bleeding index (mSBI), probing depth (PD) and
relative attachment level (RAL) as well as percentage radiographic intrabony defect depth
reduction (DDR) were recorded at baseline before surgery and 9 months post-operatively.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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