Gene Expression Profiles in Chronic Periodontitis

Chronic Periodontitis Clinical Trial

Official title:

Gene Expression Profiles in Chronic Periodontitis: A Gene Network-based Microarray Analysis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02467283
• Other study ID #: KOU KAEK 2013 / 15
• Status: Completed
• Phase: N/A
• First received: June 3, 2015
• Last updated: February 9, 2018
• Start date: February 2013
• Est. completion date: May 2017

Study information

• Verified date: February 2018
• Source: Kocaeli University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Current concepts of the causes of periodontitis implicate a bacterial infection as the primary cause of the disease. Several bacterial species residing in a biofilm on tooth surfaces are closely associated with periodontitis. Chronic periodontitis (CP) is initiated and sustained by bacterial plaque, but host defense mechanisms play an integral role in its pathogenesis.

Gene expression profiling is a powerful means of generating comprehensive genome-level data sets on diseases such as cancer, asthma, rheumatoid disorders and periodontitis, and provides significant insight information for these diseases. Gene expression profiling may provide an evidence for involving genes in the pathogenesis of CP and generate further information other than clinical signs and symptoms of CP.

The aim of this study was to identify gene-expression patterns of patients with chronic periodontitis by whole-transcriptome gene-expression analyses.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 46
• Est. completion date: May 2017
• Est. primary completion date: August 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

1. CP patients had at least 20 teeth exhibiting >30% of measured sites with >5mm clinical attachment loss.

2. Had bleeding on probing (BOP) at >50% of the proximal sites.

Exclusion Criteria:

1. Had any known systemic diseases that can influence the periodontal status, oral diseases other than chronic periodontitis and ongoing orthodontic therapy.

2. History of hepatitis, HIV infection, or diabetes; requirement for antibiotic prophylaxis, pregnancy or lactation; and long-term use of anti-inflammatory drugs.

3. Should be free of systemic diseases

4. Individuals had to be older than 18 years of age.

Related Conditions & MeSH terms

• Chronic Periodontitis
• Periodontitis

Intervention

Genetic:
• Genom-based whole-genome transcriptomic
Gene expression profiling is a powerful means of generating comprehensive genome-level data sets.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Kocaeli University

References & Publications (3)

Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol. 1999 Dec;4(1):1-6. Review. — View Citation

Demmer RT, Behle JH, Wolf DL, Handfield M, Kebschull M, Celenti R, Pavlidis P, Papapanou PN. Transcriptomes in healthy and diseased gingival tissues. J Periodontol. 2008 Nov;79(11):2112-24. doi: 10.1902/jop.2008.080139 . — View Citation

Savli H, Sunnetci D, Cine N, Gluzman DF, Zavelevich MP, Sklyarenko LM, Nadgornaya VA, Koval SV. Gene expression profiling of B-CLL in Ukrainian patients in post-Chernobyl period. Exp Oncol. 2012;34(1):57-63. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	mRNA quantification		2 months
Secondary	Gen networking map		2 months