Gene Expression Profiles in Chronic Periodontitis

Status Completed

Clinical Trial Summary

Current concepts of the causes of periodontitis implicate a bacterial infection as the primary cause of the disease. Several bacterial species residing in a biofilm on tooth surfaces are closely associated with periodontitis. Chronic periodontitis (CP) is initiated and sustained by bacterial plaque, but host defense mechanisms play an integral role in its pathogenesis.

Gene expression profiling is a powerful means of generating comprehensive genome-level data sets on diseases such as cancer, asthma, rheumatoid disorders and periodontitis, and provides significant insight information for these diseases. Gene expression profiling may provide an evidence for involving genes in the pathogenesis of CP and generate further information other than clinical signs and symptoms of CP.

The aim of this study was to identify gene-expression patterns of patients with chronic periodontitis by whole-transcriptome gene-expression analyses.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02467283
Study type	Observational
Source	Kocaeli University
Contact
Status	Completed
Phase	N/A
Start date	February 2013
Completion date	May 2017

View Details

See also
Status	Clinical Trial	Phase
Not yet recruiting	`NCT06400069` - Role of NLRP6 in Chronic Periodontitis
Completed	`NCT05231096` - Comparison of the Effect of Gingival Massage of Aloe-vera Gel and Sidr Honey on Chronic Periodontitis	N/A
Completed	`NCT03203746` - Gingival Crevicular Fluid Levels of Protein Carbonyl Following the Use of Lycopene in Chronic Periodontitis	Phase 1/Phase 2
Active, not recruiting	`NCT03354338` - Amoxicillin to Prevent Bacteria and Inflammatory Biomarkers After Intensive Periodontal Therapy	Phase 2
Completed	`NCT02516111` - Comparison of Autologous PRF, 1% Alendronate and 1.2% Atorvastatin Gel in Chronic Periodontitis Treatment	Phase 2/Phase 3
Terminated	`NCT02568163` - Influence of Stress on Non Surgical Periodontal Treatment	N/A
Completed	`NCT02174146` - Leptin and Visfatin in Diabetic Patients With Periodontitis Before and After Periodontal Therapy	N/A
Completed	`NCT02430519` - Benefits of Platelet Rich Fibrin In Mandibular Molar Furcation Defects	N/A
Completed	`NCT01233765` - Analysis of Neutrophil Response in Chronic Periodontitis	N/A
Completed	`NCT01438333` - Efficacy of INERSAN in Patients With Chronic Periodontitis as Adjunctive to Full Mouth Disinfection	N/A
Completed	`NCT02218515` - Treatment of Intrabony Periodontal Defects With Enamel Matrix Derivatives and Autogenous Bone Graft	Phase 4
Completed	`NCT02197260` - Antimicrobial Therapy as Adjunct to Periodontal Treatment: Effect of Timing	Phase 4
Not yet recruiting	`NCT03270280` - Comparison of Salivary Interleukin-1β and Matrix Metalloproteinase-8 Levels in Individuals With Chronic Periodontitis	Phase 2
Not yet recruiting	`NCT04026828` - Evaluation of Possible Genes in Periodontal Diseases by Genetic Methods
Completed	`NCT04697199` - The Adjunctive Effect of Probiotics to Non Surgical Treatment of Chronic Periodontitis	Phase 1
Completed	`NCT04643288` - Nanocrystalline Hydroxyapatite Bone Substitute for Treating Periodontal Intrabony Defects	N/A
Completed	`NCT03039244` - Evaluation of Antimicrobial Photodynamic Therapy as an Adjunct to Periodontal Treatment in Smokers	N/A
Completed	`NCT02898675` - Advantages of Autologous Platelet-Rich Fibrin Membrane on Growth Factor Levels and Periodontal Healing	N/A
Completed	`NCT02518152` - Platelet Rich Fibrin+1% Alendronate in Treatment of Chronic Periodontitis	Phase 2/Phase 3
Completed	`NCT03874390` - Effects of Ozone Therapy on Clinical Parameters and Inflammatory Cytokines in Chronic Periodontitis Patients	N/A