Chronic Periodontitis Clinical Trial
Official title:
Improvement of Periodontal Health and Reduction in Periodontal Plaque Micro-flora Using a Probiotic Lozenge in Patients With Chronic Periodontitis
Periodontal disease is a major cause of tooth loss in humans and is one of the most
prevalent diseases associated with bone loss. Following bacterial colonization, the gingiva
becomes inflamed leading, in some cases, to the destruction of the alveolar bone.
Periodontitis has two distinct but interconnected etiologic components, periodontopathic
bacteria and host-mediated connective tissue-destructive responses to the causative bacteria
and their metabolic products.
A few studies have revealed that probiotic Lactobacillus strains were useful in reducing
gingival inflammation and the number of black-pigmented rods, including Porphyromonas
gingivalis (Pg), in the saliva and sub-gingival plaque. Concerning periodontal conditions,
its shown that application of beneficial bacteria, as an adjunct to scaling and root planing
(SRP), can inhibit re-colonization of pathogens in periodontal pockets and reduce bleeding
on probing.
The aim of the present study is to evaluate the improvement of periodontal health with
probiotic (Inersan) lozenges, used as an adjunct to scaling and root planing [SRP].
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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