Chronic Presence of Epstein Barr Virus in Epithelial Cells From Gingiva is Associated With Periodontitis

Chronic Periodontitis Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01246596
• Other study ID #: 10-AOI-01
• Status: Completed
• Phase: N/A
• Start date: January 2011
• Est. completion date: May 5, 2014

Study information

• Verified date: November 2023
• Source: Centre Hospitalier Universitaire de Nice
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The etiopathogenesis of periodontal disease results from complex interaction between infectious agents, mainly including bacteria, and host cellular and humoral immune responses. However it is thought that bacteria-induced pathogenesis is not sufficient alone to explain all biological and clinical features of the destructive periodontal disease. The main hypothesis is that herpesviruses, such as Epstein-Barr Virus, may participate as well by altering epithelial gingival cell biology and consequently may promote the initiation and progression of periodontitis.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 23
• Est. completion date: May 5, 2014
• Est. primary completion date: May 5, 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• 10 patients affected by chronic periodontitis

• 10 patients affected by aggressive periodontitis

• 10 healthy patients (orthodontics extraction)

• Subject who have read and understood the information note relative under investigation and who have signed the informed consent

• major patient

Exclusion Criteria:

• Patient with no contre-indication to periodontal treatment

• Patient with serious blood disease

• Patient who exhibits systemic condition incompatible with realization of the study

• Patient treated with oral retinoids, bisphosphonates, oral anticoagulants and anticonvulsivants

• Patient who presents a buccal carcinoma treated with radiotherapy

• Patient who have received during the past 6 months: anti-inflammatory drugs, anti-cancerous or immunosuppressive chemiotherapy

• Patient who presents a linguistic or psychic incapacity to understand information

Related Conditions & MeSH terms

• Aggressive Periodontitis
• Chronic Periodontitis
• Periodontitis
• Presence / Absence of EBV

Intervention

Procedure:
• dental root planing
The objective of root planing, otherwise known as conventional periodontal therapy, non-surgical periodontal therapy, or dental prophylaxis is to remove or eliminate the etiologic agents which cause inflammation: dental plaque, its products and calculus,[1] thus helping to establish a periodontium that is free of disease.[2]
• dental root planing
The objective of root planing, otherwise known as conventional periodontal therapy, non-surgical periodontal therapy, or dental prophylaxis is to remove or eliminate the etiologic agents which cause inflammation: dental plaque, its products and calculus, thus helping to establish a periodontium that is free of disease.
• dental root planing
The objective of root planing, otherwise known as conventional periodontal therapy, non-surgical periodontal therapy, or dental prophylaxis is to remove or eliminate the etiologic agents which cause inflammation: dental plaque, its products and calculus, thus helping to establish a periodontium that is free of disease.

Locations

Country	Name	City	State
France	Dr Severine VINCENT	Nice

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire de Nice

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Percentage of gingival epithelial cells infected by EBV (by immunofluorescence and In situ Hybridization)		at time=0
Secondary	Epithelial tissue infected by EBV (by immunofluorescence and in situ hybridization)		at time = 0
Secondary	Presence / absence of latency and / or lytic proteins (by immunofluorescence and in situ hybridization)		at time = 0