Superior Hypogastric Plexus Block Versus Pulsed Radiofrequency for Chronic Pelvic Cancer Pain

Chronic Pelvic Cancer Pain Clinical Trial

Official title:

Superior Hypogastric Plexus Block and Pulsed Radiofrequency on Dorsal Root Ganglia of Sacral Nerves for Chronic Pelvic Cancer Pain

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT03228316
• Other study ID #: MEHG
• Status: Not yet recruiting
• Phase: N/A
• Start date: October 20, 2019
• Est. completion date: December 20, 2020

Study information

• Verified date: July 2019
• Source: Assiut University
• Contact: Fatma Ahmed Abdel Aal, professor
• Phone: 01113221317
• Email: Fatmaabdelal23[@]yahoo.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Cancer-related pain represents a major challenge for both clinicians and patients. This pain can be associated directly with the cancer or with certain treatments administered to the patient. 52.1% of cancer patients suffer from pain and that 62.6% are not satisfied with the current pain treatment. Pain prevalence is high in developing countries due to late diagnosis and major impediments to opioid access

Description:

pelvic cancer is a broad term encompassing malignant tumors of the bladder, prostate, cervix, endometrium, ovaries, and uterus, among others. Pain associated with pelvic cancer is one of the most debilitating symptoms experienced by affected patients. Multiple studies demonstrate that the prevalence of pain in patients with pelvic cancer is >50%, and can be upwards of 60% to 70% in patients with advanced or metastatic disease . Cancer patients with extension of tumor into the pelvis may experience severe pain. Oral or parenteral opioids may not only fail to provide relief, but may cause excessive sedation and other side effects. More invasive approaches may thus be needed to control pain and improve the quality of life. Since pelvic cancer pain is visceral in most cases, this could be achieved with percutaneous chemical neurolytic block of the superior hypogastric plexus . The superior hypogastric plexus is located at the anterior aspect of the L5 and S1 vertebrae, and traverses the disk between these levels. It is an extension of the aortic plexus below the aortic bifurcation, and contains almost exclusively sympathetic fibers and visceral afferents . Afferent pain fibers innervating pelvic organs travel with sympathetic nerves, trunks, ganglia, and rami; thus, interrupting the sympathetic chain at this level can be used to treat pelvic cancer pain. Several studies examined the use of superior hypogastric plexus block in the treatment of pelvic cancer pain. Although the authors reported a mean reduction in pain of 70%, neither the follow-up period nor the proportion with a successful prognostic block were noted. Radiofrequency utilizes a high-frequency alternating current that is passed from the needle electrode into the surrounding tissue, resulting in frictional heating and necrosis. Due to the accuracy of lesions produced by radiofrequency ablation, there has been growing interest in the use of this technique for neurolysis of nerves as it offers the potential of accurate nerve destruction ablation, with a predictable and controlled ablative lesion. Another advantage of radiofrequency ablation is that it has an immediate effect unlike alcohol and phenol, which may take up to 1 week or 10 days to achieve neurolysis .

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 40
• Est. completion date: December 20, 2020
• Est. primary completion date: June 20, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

• sympathetically maintained pelvic, perineal pain

• pain is no longer controlled with oral morphine sustained release tablets 30 mg

• excessive sedation or other side effects from oral morphine sustained release tablets 30 mg or amitryptyline tablets 25 mg

• age between 18-70 years

Exclusion Criteria:

• patient refusal

• patients with coagulopathies

• allergy to constant dyes or phenol

• patients receiving radiation or chemotherapy within 4 weeks of neurolytic block

• patients with major or moderate cardiac/respiratory incapacitating diseases

• liver and renal failure

• patients younger than 18 years and older than 70 years

Related Conditions & MeSH terms

• Cancer Pain
• Chronic Pelvic Cancer Pain
• Pelvic Neoplasms

Intervention

Procedure:
• superior hypogastric plexus block
nerve plexus block

Radiation:
• pulsed radiofrequency
pulsed radiofrequency on sacral nerve roots 2,3 and 4

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

References & Publications (1)

Sindt JE, Brogan SE. Interventional Treatments of Cancer Pain. Anesthesiol Clin. 2016 Jun;34(2):317-39. doi: 10.1016/j.anclin.2016.01.004. Review. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Visual analogue score for pain	Points on a scale	2 months