Effectiveness of Repetitive Transcranial Magnetic Stimulation in the Treatment of Chronic Neuropathic Pain

Chronic Neuropathic Pain Clinical Trial

— rTMS-CIC  

Official title:

Effectiveness of Repetitive Transcranial Magnetic Stimulation in the Treatment of Chronic Neuropathic Pain: Retrospective Study on a Cohort of 149 Patients at Rennes University Hospital, From January 2014 to December 2015

Clinical Trial Details — Status: Withdrawn

Administrative data

• NCT number: NCT03259451
• Other study ID #: 35RC16_3045_rTMS-CIC
• Status: Withdrawn
• First received: August 21, 2017
• Last updated: April 11, 2018
• Start date: September 26, 2016
• Est. completion date: December 31, 2017

Study information

• Verified date: April 2018
• Source: Rennes University Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

A retrospective, monocentric, observational, descriptive, open study of a cohort of 149 patients from January 2014 to December 2015

Description:

Neuropathic pain is a public health problem because of its prevalence reaching nearly 7% of the general population and the effectiveness of current treatments often remains incomplete: only 30-40% of patients are relieved of 50% of their pain by a pharmacological approach.

As early as the 1990s, stimulation of the motor cortex by implanted electrodes made it possible to successfully treat certain chronic refractory neuropathic pain. In 1995 it was reported that the application of repeated shocks by transcranial magnetic stimulation of the motor cortex could induce an analgesic effect in a patient suffering from neuropathic pain.

This technique has proved its analgesic efficacy after an induction treatment over 5 days, in the context of chronic pain (neuropathic or fibromyalgia), but all the patients are not responders and there is currently, Of predictive criteria for response. It seems important to continue studies on this non-medicinal, non-invasive therapy with no significant adverse effects.

Recruitment information / eligibility

• Status: Withdrawn
• Enrollment: 0
• Est. completion date: December 31, 2017
• Est. primary completion date: December 31, 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• patient older than 18 years old with chronic neuropathic pain who are resistant to drug therapy for which treatment with rTMS is indicated between January 2014 and December 2015

Exclusion Criteria:

• Patient less than 18 years old

• Pregnant woman

• Non-neuropathic pain

• Pain <6 months

• Unbalanced epilepsy

• Patient with a contraindication for cerebral MRI (cochlear implant, ocular metallic foreign bodies, patient with a pacemaker, mechanical valve)

• Psychiatric pathology

• Person subject to major legal protection (safeguarding justice, guardianship, trusteeship), persons deprived of liberty

Related Conditions & MeSH terms

• Chronic Neuropathic Pain
• Neuralgia

Intervention

Device:
• Repetitive Transcranial Magnetic Stimulation (rTMS)

Locations

Country	Name	City	State
France	CHU de Rennes	Rennes

Sponsors (1)

Lead Sponsor	Collaborator
Rennes University Hospital

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Evaluation of the efficacy of rTMS in the treatment of chronic neuropathic pain in a short term	Improvement of pain symptoms by at least 30% on the numerical scale	Day 7
Primary	Evaluation of the efficacy of rTMS in the treatment of chronic neuropathic pain in a short term (= 1 month)	Improvement of pain symptoms by at least 30% on the numerical scale	Month 1
Secondary	Evaluate the effectiveness of rTMS in the treatment of long-term chronic neuropathic pain (> 6 months)	Persistence of at least 30% improvement in pain symptoms on a numerical scale at the end of the sixth month (M6)	Month 6