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NCT01010256 Clinical Trial

The Expression of PTEN Protein and mRNA in Malignant Cells of Chronic Myelomonocytic Leukemia

Chronic Myelomonocytic Leukemia Clinical Trial

Official title:
The Expression of PTEN Protein and mRNA in Malignant Cells of Chronic Myelomonocytic Leukemia

Clinical Trial Details — Status: Terminated

Administrative data
NCT number NCT01010256
Other study ID # 111245
Secondary ID
Status Terminated
Phase
First received
Last updated
Start date November 1, 2009
Est. completion date October 3, 2019

Study information
Verified date February 2020
Source University of Arkansas
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The purpose of this study is to evaluate the level of a specific protein (PTEN) in the cancer cells of chronic myelomonocytic leukemia (CMML) patients. This protein might be involved in the transformation from normal blood cells to leukemia cells. The PTEN protein has not been investigated in CMML specifically but it has been discovered in closely related cancers. If this study demonstrates an abnormality in this protein, future testing will be designed to evaluate the genetic abnormality that resulted in lack of the normal presence of this protein. The goal is that the results of this study will help to develop new drugs and strategies to treat the future patients with CMML by understanding the abnormality of the disease at the cellular and molecular levels. The results of this study can also be utilized by future studies to develop individualized treatment to patients who have abnormal levels of this protein.

Recruitment information / eligibility
Status Terminated
Enrollment 4
Est. completion date October 3, 2019
Est. primary completion date October 3, 2019
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria:

- Subject must be at least 18 years or older.

- Subject must sign informed consent.

- For study population only, the subject must have a CMML diagnosis based on the WHO 2009 criteria.

- For control population only, the subject must be deemed healthy with no hematologic disorders.

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
United States University of Arkansas for Medical Sciences Little Rock Arkansas

Sponsors (1)
Lead Sponsor Collaborator
University of Arkansas

Country where clinical trial is conducted

United States, 

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