Chronic Myelomonocytic Leukemia Clinical Trial
Official title:
Prevention of DMSO-Related Nausea and Vomiting by Prophylactic Administration of Ondansetron for Patients Receiving Autologous Cryopreserved Peripheral Blood Stem Cells
RATIONALE: Ondansetron may help lessen or prevent nausea and vomiting in patients undergoing
stem cell transplant.
PURPOSE: This phase II trial is studying how well ondansetron works in preventing nausea and
vomiting in patients undergoing stem cell transplant.
OBJECTIVES:
I. To determine whether the incidence of nausea, retching and vomiting related to
administration of autologous hematopoetic stem cells cryopreserved in DMSO can be reduced by
the use of a single dose of intravenous ondansetron prior to the stem cell infusion.
II. To determine the number of patients who experience nausea and vomiting.
OUTLINE: Patients receive ondansetron IV once 30-60 minutes before undergoing autologous
peripheral blood stem cell transplantation.
;
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Supportive Care
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