Clinical Trials Logo
  1. Home
  2. Chronic Myeloid Leukemia
  3. NCT05311943

Treatment With Olverembatinib in CML-CP Patients Who Failed to at Least Two Previously Administered Second-generation TKIs.

Chronic Myeloid Leukemia, Chronic Phase Clinical Trial

Official title:
Treatment With Olverembatinib in Chronic Phase Chronic Myeloid Leukemia Patients Who Failed to at Least Two Previously Administered Second-generation Tyrosine Kinase Inhibitors: a Prospective, Single-arm Clinical Trial.

Clinical Trial Summary

The purpose of this trial is to evaluate the efficacy and safety of olverembatinib(HQP1351) in patients with chronic myeloid leukemia in chronic phase (CML-CP) who are resistant and/or intolerant to at least two second-generation tyrosine kinase inhibitors. The efficacy of olverembatinib is determined by evaluating the major molecular responses(MMR) at the and of 12 months.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05311943
Study type Interventional
Source Shenzhen Second People's Hospital
Contact Xin Du, Phd
Phone 075583366388
Email duxingz@medmail.com.cn
Status Recruiting
Phase Phase 3
Start date July 1, 2022
Completion date June 30, 2025
View Details
See also
  Status Clinical Trial Phase
Not yet recruiting NCT06409936 - PEARL Study: PotEntial of Asciminib in the eaRly Treatment of CML Phase 2
Terminated NCT04006847 - Omega -3 Fatty Acid in Combination With Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia Phase 1/Phase 2
Not yet recruiting NCT06368414 - A Study of Treatment-free Remission in Chronic Phase Chronic Myeloid Leukemia Phase 2
Active, not recruiting NCT04126681 - A Pivotal Study of HQP1351 in Patients With Chronic Myeloid Leukemia in Chronic Phase Phase 2
Not yet recruiting NCT05543161 - "Peripheral Blood Dipeptidylpeptidase IV (CD26) Positive Leukemic Stem Cells in Chronic Myeloid Leukemia as a Diagnostic Marker"
Recruiting NCT05638763 - Cytochrome P450 Inhibition to Decrease Dosage of Dasatinib for Chronic Myelogenous Leukemia Phase 2
Recruiting NCT03610971 - Treatment Free Remission After Combination Therapy With Ruxolitinib Plus Tyrosine Kinase Inhibitors Phase 2
Completed NCT03332511 - Efficacy and Safety of Nilotinib in CML-CP Phase 4
Active, not recruiting NCT06233890 - The Analysis of Fatigue on Tyrosine Kinase Inhibitor Therapy in Chronic Myeloid Leukaemia
Completed NCT03882281 - Pharmacokinetics Profiles of HQP1351 Under Fasting and High-fat Meals in Patients With Chronic Myeloid Leukemia Phase 1
Recruiting NCT03459534 - A Phase 3 Study for the Efficacy and Safety of Radotinib in CP-CML Patients With Failure or Intolerance to Previous TKIs Phase 3
Completed NCT03885830 - Precision Dosing of Tyrosine Kinase Inhibitors in CML Patients
Active, not recruiting NCT04147533 - Efficacy and Safety of TKIs' Withdrawal After a Two-step Dose Reduction in Patients With Chronic Myeloid Leukemia Phase 2
Recruiting NCT03942094 - Nilotinib for First-line Newly Diagnosed CML-CP Patients Phase 3
Active, not recruiting NCT03933852 - Observational Study on Chronic Myeloid Leukemia Patients in Any Phase Treated With Ponatinib (Iclusig®) at Any Dose
Active, not recruiting NCT04160546 - Study to Evaluate the Reinduction and Second Stop of TKI With Ponatinib in CML in Molecular Response (ResToP) Phase 2
Recruiting NCT04677439 - Flumatinib in CML-CP Patients With Ph+ Post Imatinib Failure Phase 4
Active, not recruiting NCT03722420 - Randomized Evaluation of Radotinib Versus Imatinib in Phase III Study for Efficacy With Chinese Patients (RERISE China) Phase 3
Not yet recruiting NCT06163430 - CARDINAL- A Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of TERN-701 in Participants With Chronic Myeloid Leukemia Phase 1
Completed NCT02977312 - Study of Cemivil® (Imatinib) in Chronic Myeloid Leukemia Patients in Jordan N/A