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Clinical Trial Summary

The purpose of this study is to find the maximum dose of huCART19-IL18 cells that is safe for use in humans with CD19+ cancers.


Clinical Trial Description

This is a Phase I dose finding study to determine the maximum tolerated dose (MTD) and assess the safety, tolerability, manufacturing feasibility, pharmacokinetics, and preliminary efficacy of huCART19-IL18 cells in patients with CD19+ cancers. Up to 7 total dose levels will be evaluated using the Bayesian Optimal Interval (BOIN) design with accelerated titration in order to determine the maximum tolerated dose (MTD) of huCART19-IL18 cells within each of the following disease-specific cohorts: - Cohort A: Non-Hodgkin Lymphoma (NHL) - Cohort B: Chronic Lymphocytic Leukemia (CLL) - Cohort C: Acute Lymphoblastic Leukemia (ALL) ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04684563
Study type Interventional
Source University of Pennsylvania
Contact Abramson Cancer Center Clinical Trials Service
Phone 855-216-0098
Email PennCancerTrials@careboxhealth.com
Status Recruiting
Phase Phase 1
Start date May 6, 2021
Completion date May 2036

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