A Study of Venetoclax and Rituximab/Hyaluronidase Human in Relapsed/Refractory CLL

Chronic Lymphocytic Leukemia Clinical Trial

Official title:

A Phase II Study of Venetoclax and Rituximab/Hyaluronidase Human in Relapsed/Refractory CLL

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT03467867
• Other study ID #: 2017-1502
• Status: Active, not recruiting
• Phase: Phase 2
• Start date: April 26, 2018
• Est. completion date: October 2024

Study information

• Verified date: April 2024
• Source: Georgetown University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This is an open-label, multicenter, Phase II study to investigate the efficacy and safety of venetoclax in combination with Rituximab/hyaluronidase human in participants with relapsed or refractory chronic lymphocytic leukemia (CLL).

Description:

The study has one arm and all the patients will receive venetoclax and rituximab.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 25
• Est. completion date: October 2024
• Est. primary completion date: October 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Signed Informed Consent Form

• Ability and willingness to comply with the requirements of the study protocol

• Patient must have diagnosis of CLL that meets published 2008 IWCLL NCI-WG criteria.

• Patient must have relapsed/refractory disease with an indication for treatment.

• Patient must have an Eastern Cooperative Oncology Group (ECOG) performance score of = 2

• Adequate hematologic function (unless caused by underlying disease, as established by extensive bone marrow involvement or as a result of hypersplenism secondary to the involvement of the spleen by lymphoma per the investigator) defined as follows:

• Hemoglobin (> / =) 9 g/dL

• Absolute neutrophil count (> / =) 1.0 x 109/L

• Platelet count (> / =)75 x 109/L

• Adequate renal function, as indicated by:

• Calculated creatinine clearance = 30 mL/min using 24-hour Creatinine Clearance or modified Cockcroft-Gault equation (eCCR; with the use of ideal body mass [IBM] instead of mass)

• Adequate liver function, as indicated by:

• AST or ALT (< / =) 2.5 x ULN

• Total bilirubin < 1.5 x ULN (or (< / =) 3 x ULN for patients with documented Gilbert syndrome)

• Female patients who are not of child-bearing potential and female patients of child-bearing potential who have a negative serum pregnancy test within 3 days prior to Cycle 1, Day 1.

• Patients with HIV infection could be included in the study, as long as their disease is under control on anti-retroviral therapy. Precautions should be taken to modify their HAART regimen to minimize drug interaction

• Warfarin is considered a cautionary medication. Patients on warfarin will be encouraged to replace warfarin with other anticoagulants if possible. If it is not possible or patient is not willing to switch, they could still be included in the study with caution.

Exclusion Criteria:

• Known hypersensitivity to any of the study drugs

• Allogeneic stem cell transplant within the past 1 year.

• Richter's transformation confirmed by biopsy

• History of other malignancy that could affect compliance with the protocol or interpretation of results

• Patients with a history of curatively treated basal or squamous cell carcinoma or Stage 1 melanoma of the skin or in situ carcinoma of the cervix are eligible.

• Patients with a malignancy that has been treated with surgery alone with curative intent will be included. Individuals in documented remission without treatment for (> / =) 2 years prior to enrollment may be included at the discretion of the investigator.

• Evidence of significant, uncontrolled concomitant diseases that could affect compliance with the protocol or interpretation of results or that could increase risk to the patient, including renal disease that would preclude chemotherapy administration or pulmonary disease (including obstructive pulmonary disease and history of bronchospasm)

• Known active bacterial, viral, fungal, mycobacterial, parasitic, or other infection (excluding fungal infections of nail beds) at study enrollment, or any major episode of infection requiring treatment with IV antibiotics or hospitalization (relating to the completion of the course of antibiotics) within 4 weeks prior to Cycle 1, Day 1

• Received the following agents within 7 days prior to the first dose of venetoclax:

• Steroid therapy for anti-neoplastic intent

• Strong and moderate CYP3A inhibitors

• Strong and moderate CYP3A inducers

• Consumed grapefruit, grapefruit products, Seville oranges (including marmalade containing Seville oranges), or star fruit within 3 days prior to the first dose of venetoclax

• Clinically significant history of liver disease, including viral or other hepatitis, current alcohol abuse, or cirrhosis

• Presence of positive test results for hepatitis B virus (HBV), hepatitis B surface antigen (HBsAg), or hepatitis C (HCV) antibody

• Patients who are positive for HCV antibody must be negative for HCV by polymerase chain reaction (PCR) to be eligible for study participation

• Patients with occult or prior HBV infection (defined as positive total hepatitis B core antibody [HBcAb] and negative HBsAg) may be included if HBV DNA is undetectable. These patients must be willing to undergo monthly DNA testing.

• Known infection with human T-cell leukemia virus 1 (HTLV-1)

• Patients with uncontrolled HIV infection

• Receipt of live-virus vaccines within 28 days prior to the initiation of study treatment or need for live-virus vaccines at any time during study treatment

• Pregnant or lactating, or intending to become pregnant during the study Women of childbearing potential must have a negative serum pregnancy test result within 21 days prior to initiation of study drug.

• Recent major surgery (within 6 weeks prior to the start of Cycle 1, Day 1) other than for diagnosis

• Malabsorption syndrome or other condition that precludes enteral route of administration

• Known allergy to both xanthine oxidase inhibitors and rasburicase

Related Conditions & MeSH terms

• Chronic Lymphocytic Leukemia
• Leukemia
• Leukemia, Lymphocytic, Chronic, B-Cell
• Leukemia, Lymphoid

Intervention

Drug:
• Venetoclax
Venetoclax will be administered as described in the reporting arm.
• Rituximab
Rituximab (IV) will be administered as described in the reporting arm.
• Rituximab/Hyaluronidase Human
Rituximab/Hyaluronidase Human (SC) ill be administered as described in the reporting arm.

Locations

Country	Name	City	State
United States	John Theurer Cancer Center at Hackensack University Medical Center	Hackensack	New Jersey
United States	Georgetown University Medical Center	Washington	District of Columbia

Sponsors (2)

Lead Sponsor	Collaborator
Georgetown University	Hackensack Meridian Health

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Overall Response Rate (ORR)	Percentage of Participants With Best Overall Response (OR)(Defined as Complete Response [CR], Initial CR [CRi], Nodular Partial Response [nPR], PR) as Assessed by Investigator Determined Using iwCLL Guidelines	Baseline up to disease progression or death, whichever occurs first (up to approximately 5 years)
Secondary	Disease Response	Percentage of Participants With Disease Response (OR, CR, CRi, nPR, PR) as Assessed by Investigator Determined Using iwCLL Guidelines at end of Combination Treatment Visit	12 weeks after Day 1 of last cycle of combination therapy (approximately 5 years, cycle length= 28 days)
Secondary	Duration of Responses (DOR)	Duration of Responses (DOR)	Baseline up to disease progression or death, whichever occurs first (up to approximately 5 years)
Secondary	Time to Progression (TTP)	Time to progression will be defined as the time from the date of first dose (date of enrollment if not dosed) to the date of earliest disease progression (per the investigator assessment).	Baseline up to disease progression or death, whichever occurs first (up to approximately 5 years)
Secondary	Progression-Free Survival (PFS)	Investigator-Assessed Progression-Free Survival (PFS) Determined Using Standard International Workshop on Chronic Lymphocytic Leukemia (iwCLL) Guidelines	Baseline up to disease progression or death, whichever occurs first (up to approximately 5 years) ]
Secondary	Overall Survival (OS)	Overall Survival (OS)	Baseline up to death (up to approximately 5 years)
Secondary	Time to Next Anti-CLL Treatment (TTNT)	Time to Next Anti-CLL Treatment (TTNT)	Baseline up to disease progression or death, whichever occurs first (up to approximately 5 years) ]
Secondary	Percentage of Participants With Minimal Residual Disease (MRD)	Percentage of Participants With Minimal Residual Disease (MRD) Negativity at End of Combination Treatment Response Visit	12 weeks after Day 1 of last cycle of combination therapy (up to approximately 5 years, cycle length= 28 days) ]