Chronic Lymphocytic Leukemia Clinical Trial
Official title:
A Phase I Study of Lenalidomide in Combination With Rituximab and Ibrutinib in Relapsed and Refractory CLL and SLL
This study is for subjects diagnosed with recurrent or relapsed CLL/SLL. The purpose of this
study is to test the safety of the combination of the drugs lenalidomide and ibrutinib at
different dose levels, in combination with the drug rituximab. We want to find out what
effects, good and/or bad, they have on patients with CLL/SLL.
The hypothesis of the study is that it will be safe to give the three drugs in combination
and the information learned from this trial will be used to study the 3 drug combination is a
larger future trial.
Treatment consists of dose escalations of lenalidomide and ibrutinib and fixed doses of rituximab. A small expansion cohort to include 10 patients will follow once the recommended phase II dose is found. ;
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