Chronic Lymphocytic Leukemia Clinical Trial
Official title:
Genomic Analysis of Patients With Chronic Lymphocytic Leukemia
This study aims to characterize clonal evolution in chronic lymphocytic leukemia (CLL) using
different approaches and to identify a possible association with disease progression, i.e.
therapy initiation.
1. Samples This monocentric study is carried out using representative bioarchived leukemic
samples with a diagnosis of CLL, either at diagnosis or at evolution. These bioarchived
samples were collected locally at our center during years of diagnostic activity, and
were accurately pathologically, cytogenetically and molecularly characterized.
2. Clinical data The clinical data were retrospectively collected through collaboration
with the referring physicians.
3. Methods Samples will be investigated by means of (1) conventional cytogenetics, (2)
fluorescence in situ hybridization (FISH) and (3) SNP-arrays. After analysis of the
array data sets, significant results will be validated and in addition, results will be
correlated with clinical data.
n/a
Observational Model: Cohort, Time Perspective: Retrospective
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