Chronic Lymphocytic Leukemia Clinical Trial
Official title:
Study of Natural Killer Cells Function in Untreated Patients With Chronic Lymphocytic Leukemia
Purpose:
The involvement of Natural Killer cells (NK) in the efficiency of the treatment in lymphoma
and the beginning of new therapies based on function and activation of NK, justify an
improvement of knowledge about the status of the population of NK (number, function, genic
expression) in Chronic Lymphocytic Leukemia (CLL).
Method: prospective, monocentric, descriptive study
Primary objective:
Evaluation of the expression and function of receptors activator of NK cell (KIRs) in
patients with CLL at stage A with therapeutic abstention, or stage B or C which require a
treatment.
Secondary objectives:
Measure of the evolution of cytotoxic function of NK cells and theirs biomarkers of
activation when the patient receives an immunochemotherapy with Rituximab/ Fludarabine/
Cyclophosphamide (RCF).
Verification, by analysis, of functions and biomarkers of the adaptive and innate immunity
;
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
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