Diuretic/Cool Dialysate Trial — DIDIT  

Chronic Kidney Insufficiency Clinical Trial

Official title: Diuretic/Cool Dialysate Trial

Status Terminated

Clinical Trial Summary

The proposed pilot study challenges the current widespread paradigm of discontinuing loop diuretics when initiating chronic HD and/or maintaining the dialysate at a constant temperature of 37 °C for all patients.

Clinical Trial Description

This pilot/feasibility RCT will recruit for 18 months and demonstrate the feasibility and safety of performing a large scale study of diuretic use and/or cool dialysate examining recruitment, retention, and key outcomes. This study will further assess whether the use of a diuretic compared to non-use of a diuretic and/or the use of cool dialysate (35.5 ºC) compared to 37 ºC for up to 6 months will improve residual renal function (RRF), improve health reported quality of life (HRQOL) and reduce hospitalizations by randomizing 20 dialysis-naïve patients (started chronic HD in the last three months) from DCI centers in the greater Albuquerque area, to either bumetanide and cool dialysate randomized in a two-by-two factorial distribution. ;

Related Conditions & MeSH terms

• Chronic Kidney Insufficiency
• Renal Insufficiency
• Renal Insufficiency, Chronic

• NCT number: NCT02593526
• Study type: Interventional
• Source: University of New Mexico
• Status: Terminated
• Phase: N/A
• Start date: January 2017
• Completion date: May 27, 2022