Chronic Kidney Failure Clinical Trial
Official title:
Chronic Kidney Disease in Relation to Alterations in Protein and Amino Acid Metabolism and Function
Weight loss commonly occurs in patients with chronic kidney disease (CKD), negatively
influencing their quality of life, treatment response and survival. Loss of muscle protein
is generally a central component of weight loss in CKD patients but patients also have
reductions in fat mass and bone density, independent of the severity of the disease state.
Attempts to reverse weight and muscle loss in CKD and improve nutritional status by
nutritional supplementation have been unsuccessful and there are currently no approved
therapies.
Purpose of this study is to provide detailed insight in disease related gut function by
obtaining information on gut permeability, digestion and absorption of glucose, fat and
protein in CKD patients compared to matched healthy controls. Additionally, to examine
whether protein and amino acid metabolism is disturbed in CKD patients compared to healthy
controls. This will provide required information that will lead to implement new strategies
to develop optimal nutritional regimen in order to enhance nutritional status, quality of
life and survival in relation to kidney disease.
This study involves one test day of approximately 7-8 hours. On this test day subjects will ingest a sugar drink to assess gut permeability and gut function, and a protein meal to measure digestion/absorption and the anabolic response to food intake. Subjects will also receive a mixture of amino acids that are made a little heavier than normal, called stable isotopes. This stable isotopes is used to investigate protein behavior in the body (protein kinetics). Blood (100-120 ml in total) and urine samples will be collected over 7.5 hours. ;
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Supportive Care
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