Prevalance Of Helicobacter Pylori Infection In Chonic Kidney Diseased Patient Admitted To Luxor Medical Complex

Chronic Kidney Diseases Clinical Trial

Official title:

Prevalance Of Helicobacter Pylori Infection In Chonic Kidney Diseased Patient Admitted To Luxor Medical

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06371001
• Other study ID #: Helicobacter Pyloi and CKD
• Status: Not yet recruiting
• Start date: May 1, 2024
• Est. completion date: July 1, 2025

Study information

• Verified date: April 2024
• Source: Assiut University
• Contact: Gehad Abdel shafy, Resident
• Phone: 01125577928
• Email: gehadabdelshafy980[@]gmail.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Detect prevalence of Helicobacter pylori infection in chronic kidney diseased patient admitted to Luxor medical complex and possible role of Helicobacter pylori in pathogenesis of chronic kidney diseased patient of unknown etiology

Description:

Helicobacter Pylori bacteria is the main pathogenic organism that settles on the gastric mucosa of more than half the human population around the world, with more prominence in the developing countries. H. Pylori had been found to be the main factor in acute and chronic gastritis, peptic ulcer diseases, and in most cases gastric malignancy. Beside to some extra gastro-intestinal diseases. Such as cardiac, pulmonary, renal and hematological diseases.

Another study showed a significant higher proteinuria in H. Pylori infected patients compared to non-infected individuals. Helicobacter pylori is a gram-negative bacterium infecting both children and adults. It is the most common human chronic infection, causing gastrointestinal diseases such as gastric malignancies, gastritis, and ulcerative diseases. H. pylori can also be involved in other non gastrointestinal infections such as diabetes and metabolic syndrome, heart disease, hematologic disorders, cancer, and chronic kidney disease (CKD) as well as chronic renal failure (CRF).

Some chronic renal failure patients who have received hemodialysis for long periods complained of gastrointestinal troubles. It has been postulated that high urea concentration makes the gastric mucosa of these patients more susceptible to H. pylori colonization. Previous observations in different countries reported the prevalence of H. pylori infection among patients with CRF ranging between 20 and 60%, and H. pylori infection can contribute to progressive renal dysfunction resulting in CKD development. In patients without established gastric dysfunction, the presence of H pylori infection was associated with increased risk for Chronic kidney dusease however, patients with both atrophic gastritis (AG) and Helcobacter pylori infection appeared to be at decreased risk for Chronic kidney disease compared with control participants.

For the H. pylori-positive patients with peptic ulcer, H. pylori infection may be a risk factor resulting in kidney damage and H. pylori eradication probably benefits to kidney damage relief and chronic kidney disease prevention.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 122
• Est. completion date: July 1, 2025
• Est. primary completion date: May 1, 2025
• Gender: All
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

• All patients aged >18 years old with chronic kidney disease of different etiology based on clinical examination, laboratory investigations and imaging

Exclusion Criteria:

1. Patients aged =18 years old.

2. Overloaded patients

3. patient with acute kidney injury

4. Patients with other GIT disease

5. pregnant female

6. patient taking aspirin, NSAID, steroid or antibiotic

7. Presence of malignancy

Related Conditions & MeSH terms

• Chronic Kidney Diseases
• Kidney Diseases
• Renal Insufficiency, Chronic

Intervention

Other:
• disease
Helicobacter Pylori Infection In Chonic Kidney Diseased Patien

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

References & Publications (4)

Hata K, Koyama T, Ozaki E, Kuriyama N, Mizuno S, Matsui D, Watanabe I, Uehara R, Watanabe Y. Assessing the Relationship between Helicobacter pylori and Chronic Kidney Disease. Healthcare (Basel). 2021 Feb 3;9(2):162. doi: 10.3390/healthcare9020162. — View Citation

Lin SY, Lin CL, Liu JH, Yang YF, Huang CC, Kao CH. Association between Helicobacter pylori infection and the subsequent risk of end-stage renal disease: a nationwide population-based cohort study. Int J Clin Pract. 2015 May;69(5):604-10. doi: 10.1111/ijcp.12602. Epub 2015 Jan 21. — View Citation

Shin SP, Bang CS, Lee JJ, Baik GH. Helicobacter pylori Infection in Patients with Chronic Kidney Disease: A Systematic Review and Meta-Analysis. Gut Liver. 2019 Nov 15;13(6):628-641. doi: 10.5009/gnl18517. — View Citation

Zizzi CF, Pellicano R, Biancone L. The relationship between Helicobacter pylori and chronic kidney disease: update 2020. Minerva Gastroenterol Dietol. 2020 Dec;66(4):343-349. doi: 10.23736/S1121-421X.20.02729-4. Epub 2020 Jul 3. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Helicobacter pylori infection and Chronic kidney diseased patient	Detect prevalence of H pylori infection in chronic kidney diseased patient admitted to Luxor medical complex hospital	1 year
Secondary	possible role of H pylori in pathogenesis of chronic kidney diseased patient of unkown etiology	possible role of H pylori in pathogenesis of chronic kidney diseased patient of unkown etiology	1 year