miRNA in Chronic Kidney Diseases

Status Not yet recruiting

Clinical Trial Summary

Oxidative stress and endoplasmic reticulum (ER) stress play a key role in tubular damage in both acute kidney injury and chronic kidney disease (CKD). Oxidative stress in the kidneys promotes renal vascular remodeling and increases preglomerular resistance. These are key elements in hypertension, acute and chronic kidney injury, as well as diabetic nephropathy. Chronic renal hypoxia is highlighted as the final common pathway to end-stage renal disease (ESRD). MicroRNA molecules (miRNA) also play an important role in these processes. MicroRNAs (miRNAs) are regulators of gene expression and play a role in the progression of renal ischemia-reperfusion injury. Although the pathophysiological contribution of microRNAs (miRNAs) to kidney damage has also been highlighted, the effect of miRNAs on kidney damage under conditions of oxidative and ER stress remains understudied.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06316284
Study type	Observational
Source	Josip Juraj Strossmayer University of Osijek
Contact	Ines Drenjancevic, MD, PhD
Phone	+38531512800
Email	ines.drenjancevic@mefos.hr
Status	Not yet recruiting
Phase
Start date	April 1, 2024
Completion date	December 31, 2026

View Details

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