Novel Equations for Estimating Lean Body Mass in Patients With Chronic Kidney Disease

Chronic Kidney Diseases Clinical Trial

Official title:

Novel Equations for Estimating Lean Body Mass in Patients With Chronic Kidney Disease

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04074278
• Other study ID #: LBM eqations
• Status: Completed
• Start date: March 1, 2013
• Est. completion date: December 1, 2015

Study information

• Verified date: September 2019
• Source: Peking University First Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Simplified methods to estimate lean body mass (LBM), an important nutritional measure representing muscle mass and somatic protein, are lacking in non-dialyzed patients with chronic kidney disease (CKD).

Objective: We developed and tested a reliable equations for estimation of LBM in daily clinical practice.

Description:

Two cross-sectional data sets were derived from outpatients with CKD stage 3-5 in Peking University First Hospital.Two equations for estimating LBM based on midarm muscle circumference (MAMC) or hand grip strength (HGS)were developed and validated in CKD patients with dual-energy x-ray absorptiometry (DEXA) as referenced gold method. Demographic data, comorbidity, and other clinical variables were also recorded.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 300
• Est. completion date: December 1, 2015
• Est. primary completion date: December 1, 2015
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• non-dialyzed patients with CKD stage 3-5

• clinical stable

• a willingness to be examined with all measurements being taken simultaneously.

Exclusion Criteria:

• systemic infections, acute cardiovascular events, operations, trauma, active hepatitis or tumor

• severe edema within one month prior to the study

• chronic infections, connective tissue disease, hyper- or hypothyroidism, amputations or pregnancy,

• taking immunosuppressive agents and anti-inflammatory medication chronically

Related Conditions & MeSH terms

• Chronic Kidney Diseases
• Kidney Diseases
• Lean Body Mass
• Renal Insufficiency, Chronic

Locations

Country	Name	City	State
China	Renal Division and Institute of Nephrology, Peking University First Hospital	Beijing	Beijing

Sponsors (1)

Lead Sponsor	Collaborator
Peking University First Hospital

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	LBM_DEXA	lean body mass measured by dual-energy x-ray absorptiometry (DEXA)	between March 1st, 2014 and December 1st, 2015