Clinical Study on the Effect of PTH on CYP3A4 Activity

Status Recruiting

Clinical Trial Summary

Parathyroid hormone (PTH) may play an important role in the down-regulation of CYP3A4 expression induced by Chronic kidney diseases (CKD). In the study of molecular mechanism, the research group found that the expression of CYP3A2 metabolic enzyme in rat liver decreased in the state of CKD.And PTH may down-regulate the expression of CYP3A4 metabolic enzyme by inhibiting the expression of Nuclear factor- Kilobuse (NF-kB) p65 subunit

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03695107
Study type	Observational
Source	The Third Xiangya Hospital of Central South University
Contact	Yang Guoping, doctor
Phone	0086 0731 88618326
Email	ygp9880@126.com
Status	Recruiting
Phase
Start date	October 2, 2019
Completion date	September 10, 2020

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