Chronic Kidney Diseases Clinical Trial
Official title:
Effects of Prebiotic Supplementation and Exercise on Inflammatory Markers, Vascular Function, Cognition, and Mental Well-being in Pre-Dialysis Kidney Patients
The study is primarily designed to examine the effect of 16 weeks of prebiotic supplementation (resistant starch)and moderate intensity aerobic training on markers of inflammation in stage 3-4 patients with chronic kidney disease.
The primary aim of the proposed study is to determine whether the consumption of a prebiotic
supplement (resistant starch) coupled with moderate intensity endurance training over 16
weeks leads to reductions in key inflammatory markers in stage 3-4 predialysis CKD patients
and whether this reduction is associated with favorable changes in vascular function and
indicators of stress and emotional reactivity.
The investigators hypothesize that supplementation with the prebiotic (resistant starch) will
lead to normalization of the microbiome of our sample of patients with chronic kidney disease
(CKD) and reduce key markers of inflammation. Reductions in these biomarkers will be
associated with favorable changes in cardiovascular variables along with indices of stress
and emotional reactivity. Moderate intensity aerobic training will have an additive
anti-inflammatory effect along with the consumption of the resistant starch.
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