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NCT03397550 Clinical Trial

The Relationship Between Salt Restriction and Taste Sensitivity in Patients With Chronic Kidney Disease

Chronic Kidney Diseases Clinical Trial

Official title:
The Relationship Between Salt Restriction and Taste Sensitivity in Patients With Chronic Kidney Disease

Clinical Trial Details — Status: Withdrawn

Administrative data
NCT number NCT03397550
Other study ID # pekingUFH-cn
Secondary ID
Status Withdrawn
Phase
First received
Last updated
Start date June 18, 2022
Est. completion date May 1, 2023

Study information
Verified date October 2022
Source Peking University First Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The compliance of salt restriction in patients with CKD may be associated with taste sensitivity.

Recruitment information / eligibility
Status Withdrawn
Enrollment 0
Est. completion date May 1, 2023
Est. primary completion date December 1, 2022
Accepts healthy volunteers
Gender All
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria: - stage 3-5 CKD patients - clinical stable Exclusion Criteria: - renal replacement therapy - cancer - systemic infection - Alzheimer's disease - acute cardiovascular events, active hepatitis - all other study-obstructive conditions

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• salt restriction education
Salt intake target:<5g/d Method:the standard salt restriction education will be lasting for 10-15 minutes by oral explanation at baseline.

Locations
Country Name City State
China Peking University First Hospital Beijing

Sponsors (1)
Lead Sponsor Collaborator
Peking University First Hospital

Country where clinical trial is conducted

China, 

References & Publications (4)

Kusaba T, Mori Y, Masami O, Hiroko N, Adachi T, Sugishita C, Sonomura K, Kimura T, Kishimoto N, Nakagawa H, Okigaki M, Hatta T, Matsubara H. Sodium restriction improves the gustatory threshold for salty taste in patients with chronic kidney disease. Kidne — View Citation

Lynch KE, Lynch R, Curhan GC, Brunelli SM. Altered taste perception and nutritional status among hemodialysis patients. J Ren Nutr. 2013 Jul;23(4):288-295.e1. doi: 10.1053/j.jrn.2012.08.009. Epub 2012 Oct 6. — View Citation

McMahon EJ, Campbell KL, Bauer JD. Taste perception in kidney disease and relationship to dietary sodium intake. Appetite. 2014 Dec;83:236-241. doi: 10.1016/j.appet.2014.08.036. Epub 2014 Sep 2. — View Citation

Middleton RA, Allman-Farinelli MA. Taste sensitivity is altered in patients with chronic renal failure receiving continuous ambulatory peritoneal dialysis. J Nutr. 1999 Jan;129(1):122-5. — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary ratings of taste sensitivity assessed by the ISO method of investigating sensitivity of taste(ISO 3972:1991) Taste sensitivity is measured by five taste solutions(salty?sour?bitter?sweet?umami). Every taste solution contains 8 different concentration. Detection , recognition and difference thresholds will be measured .Their definitions are as bellow.
Detection threshold:minimum value of sensory stimulus needed to give rise to a sensation. The sensation need not be identified.
Recognition threshold:minimum value of a sensory stimulus permitting identification of the sensation perceived.
Difference threshold:value of the smallest perceptible difference in the physical intensity of a stimulus.		 up to 12 weeks after intervention
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