Chronic Kidney Diseases Clinical Trial
Official title:
Chronic Kidney Disease: Determinants of Progression and Cardiovascular Risk. A Cohort Study in a Brazilian Population
Chronic kidney disease has become an important Public Health issue in most developed and
developing countries, with increasing incidence and prevalence rates. The cost associated
with chronic kidney disease patients is very high, derived from renal replacement therapy and
the cost associated with the high cardiovascular risk of this population. Primary and
secondary preventive measures are imperative. In this sense, the comprehension of mechanisms
and biomarkers associated with CKD progression and mortality risk in this population is an
important area of research. Cohort studies are important tools for testing risk factors and
biomarkers. Currently, CKD cohorts, particularly of those not on dialysis, are few and
restricted to North America and Europe.
The present study established a cohort of 454 CKD participants (not on dialysis) in Sao
Paulo, Brazil, who will be followed for 7-10 years. Baseline data collection was wide,
including medical history, diet (food frequency questionnaire), calcium score,
echocardiography, pulse wave velocity, cardiac frequency variability, carotid intimal media
thickness, retinography, and an extensive biobank. Follow-up is ongoing and made through
annual telephone interviews including questions on death, hospitalizations, and need of renal
replacement therapy (RRT). Vital status is investigated periodically by a hot-pursuit
strategy.
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