Removal of Beta Blocker Drugs by Hemodialysis

Chronic Kidney Diseases Clinical Trial

Official title:

Beta-blocker Dialyzability in Maintenance Hemodialysis Patients

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03361280
• Other study ID #: 104909
• Status: Completed
• Phase: Phase 1/Phase 2
• First received: November 21, 2017
• Last updated: November 27, 2017
• Start date: February 27, 2015
• Est. completion date: March 10, 2016

Study information

• Verified date: November 2017
• Source: Lawson Health Research Institute
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Eight maintenance hemodialysis patients are given one of four beta blocker drugs (atenolol, bisoprolol, carvedilol, metoprolol) three hours prior to a hemodialysis session. Blood samples and spent dialysate are collected during dialysis. On separate dialysis sessions, patients received the other study drugs until they have taken each of the four study drugs. Dialytic clearance is calculated.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 8
• Est. completion date: March 10, 2016
• Est. primary completion date: March 10, 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• at least 18 years of age, receiving hemodialysis three times per week for at least 90 days.

Exclusion Criteria:

• gastrointestinal or liver disease, body mass index greater than 40 kg/m2, contraindications for receiving a beta blocker (treatment with contraindicated medications, prior adverse reaction, severe reactive airway disease, hemodynamic instability during dialysis).

Related Conditions & MeSH terms

• Chronic Kidney Diseases
• Kidney Diseases
• Renal Insufficiency, Chronic

Intervention

Drug:
• Beta blocker
Beta blockers are administered as described in arms.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Lawson Health Research Institute

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Dialytic Clearance	Dialytic clearance calculated by the recovery clearance method	Through study completion, average of one year.
Secondary	Dialytic Clearance	Dialytic clearance calculated by the arteriovenous difference method	Through study completion, average of one year.