Chronic Kidney Disease Clinical Trial
Official title:
The Relationship Between Renal Functions and Multi Drug Resistant Organisms in Patients With Ventilator Associated Pneumonia
NCT number | NCT04833231 |
Other study ID # | omurilban1 |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | August 1, 2019 |
Est. completion date | January 31, 2021 |
Verified date | March 2024 |
Source | Konya Numune Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational [Patient Registry] |
Ventilator-associated pneumonia (VAP) is the most common nosocomial infection in patients receiving invasive mechanical ventilation (MV). Antibiotic resistance poses an increasing threat due to the rise of infections caused by multidrug-resistant organisms (MDROs).Despite the increase in the frequency of MDRO colonisation and infection in dialysis patients, it is not known enough whether the risk of multi-drug resistant (MDR) pneumonia increases in mild-to-severe chronic kidney disease (CKD) (eGFR <60 mL/min/1.73 m2) patients not receiving dialysis. Therefore, in our study, the investigators aimed to evaluate the relationship between renal functions and MDR VAP risk and the specific microbial pattern.
Status | Completed |
Enrollment | 133 |
Est. completion date | January 31, 2021 |
Est. primary completion date | January 15, 2021 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 85 Years |
Eligibility | Inclusion Criteria: - Patients of 18 years of age and above - A clinical suspicion of VAP as defined in the American Thoracic Society (ATS) guidelines - A Clinical Pulmonary Infection Score (CPIS) > 6 - No signs and symptoms of infection at the time of admission to the ICU Exclusion Criteria: - Acute kidney injury - Renal replacement treatment (RRT) - Dialysis - Renal transplantation - Active tuberculosis - Malnutrition - Immunosuppression (neutropenia, HIV positivity, transplantation, prednisone treatment of =20 mg/day, etc.) - Any extrapulmonary infection other than VAP at the time of being included in the study - Respiratory cultures presented fungal agents - Normal flora - No growth |
Country | Name | City | State |
---|---|---|---|
Turkey | Konya Numune Hospital | Konya |
Lead Sponsor | Collaborator |
---|---|
Konya Numune Hospital |
Turkey,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Multi-drug resistant (MDR) pneumonia | The presence of an infection with a resistant pathogen in patients with impaired renal function (eGFR <60 mL/min/1.73 m2) served as our primary outcome measure | 18 months |
Status | Clinical Trial | Phase | |
---|---|---|---|
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