Different Effects of Non-calcium Phosphate Binders on Serum Calcium

Status Completed

Clinical Trial Summary

Sevelamer hydrochloride (SE) can increase intestinal calcium absorption in contrast to lanthanum carbonate (LA). Study compared effect of LA and SE on serum and urine phosphate and calcium, and hormones regulating mineral-bone metabolism.

Clinical Trial Description

Recent experimental studies have shown that a non-calcium based phosphate binder sevelamer hydrochloride can increase intestinal calcium absorption in contrast to lanthanum carbonate. It is unknown whether such the difference may have an effect on bone metabolism and/or modify the development of vascular calcification in patients with chronic kidney disease. The aim of the study was to compare the effect of a single dose of 1000 mg of lanthanum carbonate with 2,4 mg of sevelamer hydrochloride on serum and urine calcium following an oral load of 5 g of calcium carbonate given with a meal with standardized phosphate content. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03451019
Study type	Interventional
Source	Medical University of Lodz
Contact
Status	Completed
Phase	Phase 4
Start date	March 1, 2018
Completion date	December 30, 2020

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